Activity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancer.
Hodgkinson, Cassandra L
Blackhall, Fiona H
Morrow, Christopher J
AffiliationClinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute; Faculty of Life Sciences and Medical and Human Sciences, Manchester Academic Health Sciences Centre, University of Manchester
MetadataShow full item record
AbstractThe monocarboxylate transporter 1 (MCT1) inhibitor, AZD3965, is undergoing phase I evaluation in the United Kingdom. AZD3965 is proposed, via lactate transport modulation, to kill tumor cells reliant on glycolysis. We investigated the therapeutic potential of AZD3965 in small cell lung cancer (SCLC) seeking rationale for clinical testing in this disease and putative predictive biomarkers for trial use.
CitationActivity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancer. 2014, 20 (4):926-37 Clin Cancer Res
JournalClinical Cancer Research
- Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma.
- Authors: Noble RA, Bell N, Blair H, Sikka A, Thomas H, Phillips N, Nakjang S, Miwa S, Crossland R, Rand V, Televantou D, Long A, Keun HC, Bacon CM, Bomken S, Critchlow SE, Wedge SR
- Issue date: 2017 Jul
- MCT1 Inhibitor AZD3965 Increases Mitochondrial Metabolism, Facilitating Combination Therapy and Noninvasive Magnetic Resonance Spectroscopy.
- Authors: Beloueche-Babari M, Wantuch S, Casals Galobart T, Koniordou M, Parkes HG, Arunan V, Chung YL, Eykyn TR, Smith PD, Leach MO
- Issue date: 2017 Nov 1
- Cellular Uptake of MCT1 Inhibitors AR-C155858 and AZD3965 and Their Effects on MCT-Mediated Transport of L-Lactate in Murine 4T1 Breast Tumor Cancer Cells.
- Authors: Guan X, Rodriguez-Cruz V, Morris ME
- Issue date: 2019 Jan 7
- Clinical significance of metabolism-related biomarkers in non-Hodgkin lymphoma - MCT1 as potential target in diffuse large B cell lymphoma.
- Authors: Afonso J, Pinto T, Simões-Sousa S, Schmitt F, Longatto-Filho A, Pinheiro C, Marques H, Baltazar F
- Issue date: 2019 Jun
- Inhibition of monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport.
- Authors: Bola BM, Chadwick AL, Michopoulos F, Blount KG, Telfer BA, Williams KJ, Smith PD, Critchlow SE, Stratford IJ
- Issue date: 2014 Dec