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    Activity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancer.

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    Authors
    Polański, Radosław
    Hodgkinson, Cassandra L
    Fusi, Alberto
    Nonaka, Daisuke
    Priest, Lynsey
    Kelly, Paul
    Trapani, Francesca
    Bishop, P
    White, A
    Critchlow, S
    Smith, P
    Blackhall, Fiona H
    Dive, Caroline
    Morrow, Christopher J
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    Affiliation
    Clinical and Experimental Pharmacology Group, Cancer Research UK Manchester Institute; Faculty of Life Sciences and Medical and Human Sciences, Manchester Academic Health Sciences Centre, University of Manchester
    Issue Date
    2014-02-15
    
    Metadata
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    Abstract
    The monocarboxylate transporter 1 (MCT1) inhibitor, AZD3965, is undergoing phase I evaluation in the United Kingdom. AZD3965 is proposed, via lactate transport modulation, to kill tumor cells reliant on glycolysis. We investigated the therapeutic potential of AZD3965 in small cell lung cancer (SCLC) seeking rationale for clinical testing in this disease and putative predictive biomarkers for trial use.
    Citation
    Activity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancer. 2014, 20 (4):926-37 Clin Cancer Res
    Journal
    Clinical Cancer Research
    URI
    http://hdl.handle.net/10541/315937
    DOI
    10.1158/1078-0432.CCR-13-2270
    PubMed ID
    24277449
    Type
    Article
    Language
    en
    ISSN
    1078-0432
    ae974a485f413a2113503eed53cd6c53
    10.1158/1078-0432.CCR-13-2270
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