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    Decreased expression of Yes-associated protein is associated with outcome in the luminal A breast cancer subgroup and with an impaired tamoxifen response.

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    Authors
    Lehn, S
    Tobin, N
    Sims, A
    Stål, O
    Jirström, K
    Axelson, H
    Landberg, Göran
    Affiliation
    Center for Molecular Pathology, Department of Laboratory Medicine, Lund University, Skåne University Hospital, 205 02 Malmö, Sweden
    Issue Date
    2014
    
    Metadata
    Show full item record
    Abstract
    Yes-associated protein (YAP1) is frequently reported to function as an oncogene in many types of cancer, but in breast cancer results remain controversial. We set out to clarify the role of YAP1 in breast cancer by examining gene and protein expression in subgroups of patient material and by downregulating YAP1 in vitro and studying its role in response to the widely used anti-estrogen tamoxifen.
    Citation
    Decreased expression of Yes-associated protein is associated with outcome in the luminal A breast cancer subgroup and with an impaired tamoxifen response. 2014, 14:119 BMC Cancer
    Journal
    BMC Cancer
    URI
    http://hdl.handle.net/10541/315922
    DOI
    10.1186/1471-2407-14-119
    PubMed ID
    24559095
    Type
    Article
    Language
    en
    ISSN
    1471-2407
    ae974a485f413a2113503eed53cd6c53
    10.1186/1471-2407-14-119
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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