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    Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis: the New EPOC randomised controlled trial.

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    Authors
    Primrose, J
    Falk, S
    Finch-Jones, M
    Valle, Juan W
    O'Reilly, D
    Siriwardena, A
    Hornbuckle, J
    Peterson, M
    Rees, M
    Iveson, T
    Hickish, T
    Butler, R
    Stanton, L
    Dixon, E
    Little, L
    Bowers, M
    Pugh, S
    Garden, O
    Cunningham, D
    Maughan, T
    Bridgewater, J
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    Affiliation
    The University of Southampton, Southampton, UK. Electronic address: j.n.primrose@soton.ac.uk
    Issue Date
    2014-04-04
    
    Metadata
    Show full item record
    Abstract
    Surgery for colorectal liver metastases results in an overall survival of about 40% at 5 years. Progression-free survival is increased with the addition of oxaliplatin and fluorouracil chemotherapy. The addition of cetuximab to these chemotherapy regimens results in an overall survival advantage in patients with advanced disease who have the KRAS exon 2 wild-type tumour genotype. We aimed to assess the benefit of addition of cetuximab to standard chemotherapy in patients with resectable colorectal liver metastasis.
    Citation
    Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis: the New EPOC randomised controlled trial. 2014: Lancet Oncol
    Journal
    The Lancet Oncology
    URI
    http://hdl.handle.net/10541/315913
    DOI
    10.1016/S1470-2045(14)70105-6
    PubMed ID
    24717919
    Type
    Article
    Language
    en
    ISSN
    1474-5488
    ae974a485f413a2113503eed53cd6c53
    10.1016/S1470-2045(14)70105-6
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