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    Comprehensive validation of cardiovascular magnetic resonance techniques for the assessment of myocardial extracellular volume.

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    Authors
    Miller, C
    Naish, J
    Bishop, P
    Coutts, Glyn
    Clark, D
    Zhao, S
    Ray, S
    Yonan, N
    Williams, S
    Flett, A
    Moon, J
    Greiser, A
    Parker, G
    Schmitt, M
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    Affiliation
    North West Heart Centre and The Transplant Centre, University Hospitalof South Manchester, Wythenshawe Hospital, Manchester, United Kingdom.
    Issue Date
    2013-05-01
    
    Metadata
    Show full item record
    Abstract
    Extracellular matrix expansion is a key element of ventricular remodeling and a potential therapeutic target. Cardiovascular magnetic resonance (CMR) T1-mapping techniques are increasingly used to evaluate myocardial extracellular volume (ECV); however, the most widely applied methods are without histological validation. Our aim was to perform comprehensive validation of (1) dynamic-equilibrium CMR (DynEq-CMR), where ECV is quantified using hematocrit-adjusted myocardial and blood T1 values measured before and after gadolinium bolus; and (2) isolated measurement of myocardial T1, used as an ECV surrogate.
    Citation
    Comprehensive validation of cardiovascular magnetic resonance techniques for the assessment of myocardial extracellular volume. 2013, 6 (3):373-83 Circ Cardiovasc Imaging
    Journal
    Circulation. Cardiovascular Imaging
    URI
    http://hdl.handle.net/10541/314895
    DOI
    10.1161/CIRCIMAGING.112.000192
    PubMed ID
    23553570
    Type
    Article
    Language
    en
    ISSN
    1942-0080
    ae974a485f413a2113503eed53cd6c53
    10.1161/CIRCIMAGING.112.000192
    Scopus Count
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