Comprehensive validation of cardiovascular magnetic resonance techniques for the assessment of myocardial extracellular volume.
Authors
Miller, CNaish, J
Bishop, P
Coutts, Glyn
Clark, D
Zhao, S
Ray, S
Yonan, N
Williams, S
Flett, A
Moon, J
Greiser, A
Parker, G
Schmitt, M
Affiliation
North West Heart Centre and The Transplant Centre, University Hospitalof South Manchester, Wythenshawe Hospital, Manchester, United Kingdom.Issue Date
2013-05-01
Metadata
Show full item recordAbstract
Extracellular matrix expansion is a key element of ventricular remodeling and a potential therapeutic target. Cardiovascular magnetic resonance (CMR) T1-mapping techniques are increasingly used to evaluate myocardial extracellular volume (ECV); however, the most widely applied methods are without histological validation. Our aim was to perform comprehensive validation of (1) dynamic-equilibrium CMR (DynEq-CMR), where ECV is quantified using hematocrit-adjusted myocardial and blood T1 values measured before and after gadolinium bolus; and (2) isolated measurement of myocardial T1, used as an ECV surrogate.Citation
Comprehensive validation of cardiovascular magnetic resonance techniques for the assessment of myocardial extracellular volume. 2013, 6 (3):373-83 Circ Cardiovasc ImagingJournal
Circulation. Cardiovascular ImagingDOI
10.1161/CIRCIMAGING.112.000192PubMed ID
23553570Type
ArticleLanguage
enISSN
1942-0080ae974a485f413a2113503eed53cd6c53
10.1161/CIRCIMAGING.112.000192
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