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    Thrombosis in ovarian cancer: a case control study.

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    Authors
    Metcalf, Robert
    Fry, D J
    Swindell, Ric
    McGurk, Antony
    Clamp, Andrew R
    Jayson, Gordon C
    Hasan, Jurjees
    Issue Date
    2014-01-21
    
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    Abstract
    Background:Thrombotic events are common in cancer patients and have been associated with an adverse prognosis in large registry-based studies.Methods:A retrospective cohort of 417 patients with ovarian cancer treated at a tertiary cancer centre between 2006 and 2009 was studied to identify the incidence and risk factors for thrombotic events and the prognostic impact of thrombosis. Patient outcomes were evaluated against a matched control group without thrombosis.Results:Ninety-nine thrombotic events occurred in 90 patients (21.6%) from 8 months before diagnosis to 56 months following diagnosis, peaking in the 4 months following diagnosis. Patients with thrombosis were older (mean 65 vs 61 years, P=0.007), had a worse performance status (PS 2: 29.9% vs 9.5%, P<0.0001) and had a more advanced FIGO stage (FIGO III/IV 75.6% vs 56.9%, P<0.0001) than patients without thrombosis. Shorter overall survival was seen in patients with pulmonary embolism and pelvic/lower limb deep vein thrombosis than without thrombosis (P=0.001). When the control group was matched for stage and PS, no survival difference was seen (P=0.91).Conclusion:Ovarian cancer patients with thrombotic events had a shorter survival. However, when matched for prognostic factors (PS and FIGO stage), thrombosis did not impact upon prognosis.British Journal of Cancer advance online publication, 21 January 2014; doi:10.1038/bjc.2014.3 www.bjcancer.com.
    Citation
    Thrombosis in ovarian cancer: a case control study. 2014: Br J Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/314869
    DOI
    10.1038/bjc.2014.3
    PubMed ID
    24448364
    Type
    Article
    Language
    en
    ISSN
    1532-1827
    ae974a485f413a2113503eed53cd6c53
    10.1038/bjc.2014.3
    Scopus Count
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