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dc.contributor.authorHoskin, P
dc.contributor.authorKirkwood, A
dc.contributor.authorPopova, B
dc.contributor.authorSmith, P
dc.contributor.authorRobinson, M
dc.contributor.authorGallop-Evans, E
dc.contributor.authorColtart, S
dc.contributor.authorIllidge, Timothy M
dc.contributor.authorMadhavan, K
dc.contributor.authorBrammer, C
dc.contributor.authorDiez, P
dc.contributor.authorJack, A
dc.contributor.authorSyndikus, I
dc.date.accessioned2014-03-27T09:49:09Z
dc.date.available2014-03-27T09:49:09Z
dc.date.issued2014-02-21
dc.identifier.citation4 Gy versus 24 Gy radiotherapy for patients with indolent lymphoma (FORT): a randomised phase 3 non-inferiority trial. 2014: Lancet Oncolen
dc.identifier.issn1474-5488
dc.identifier.pmid24572077
dc.identifier.doi10.1016/S1470-2045(14)70036-1
dc.identifier.urihttp://hdl.handle.net/10541/314865
dc.description.abstractFollicular lymphoma has been shown to be highly radiosensitive with responses to doses as low as 4 Gy in two fractions. This trial was designed to explore the dose response for follicular lymphoma comparing 4 Gy in two fractions with 24 Gy in 12 fractions METHODS: FORT is a prospective randomised, unblinded, phase 3 non-inferiority study comparing radiotherapy given as 4 Gy in two fractions with a standard dose of 24 Gy in 12 fractions. Entry criteria included all patients aged over 18 years, having local radiotherapy for radical or palliative local control, with follicular lymphoma or marginal zone lymphoma, who had received no previous treatment for at least 1 month before. The primary outcome was time to local progression analysed on an intention-to-treat basis. Randomisation was centralised through the Cancer Research UK and University College London Cancer Trials Centre. Radiotherapy target sites were randomised (1:1) with minimisation stratified by histology (follicular lymphoma vs marginal zone lymphoma), treatment intent (palliative or curative) and centre. This trial is registered with ClinicalTrials.gov number, NCT00310167.
dc.languageENG
dc.language.isoenen
dc.rightsArchived with thanks to The lancet oncologyen
dc.title4 Gy versus 24 Gy radiotherapy for patients with indolent lymphoma (FORT): a randomised phase 3 non-inferiority trial.en
dc.typeArticleen
dc.identifier.journalThe Lancet Oncologyen
dc.description.collectionLymphoma Research Teamen
html.description.abstractFollicular lymphoma has been shown to be highly radiosensitive with responses to doses as low as 4 Gy in two fractions. This trial was designed to explore the dose response for follicular lymphoma comparing 4 Gy in two fractions with 24 Gy in 12 fractions METHODS: FORT is a prospective randomised, unblinded, phase 3 non-inferiority study comparing radiotherapy given as 4 Gy in two fractions with a standard dose of 24 Gy in 12 fractions. Entry criteria included all patients aged over 18 years, having local radiotherapy for radical or palliative local control, with follicular lymphoma or marginal zone lymphoma, who had received no previous treatment for at least 1 month before. The primary outcome was time to local progression analysed on an intention-to-treat basis. Randomisation was centralised through the Cancer Research UK and University College London Cancer Trials Centre. Radiotherapy target sites were randomised (1:1) with minimisation stratified by histology (follicular lymphoma vs marginal zone lymphoma), treatment intent (palliative or curative) and centre. This trial is registered with ClinicalTrials.gov number, NCT00310167.


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