GATA3 shows differential immunohistochemical expression across thyroid and parathyroid lesions.
Abstract
Transcription factors have proved highly specific immunohistochemical markers e.g. TTF-1 (thyroid/lung) and CDX-2 (Gastro-intestinal). GATA3 is a transcription factor which is functionally involved with the development of breast, urothelial, epidermal, T lymphocyte and parathyroid tissue. Recent studies of GATA3 immunoprofile, including that by Miettinen et al. across 2040 epithelial malignancies and 460 mesenchymal or neuroectodermal neoplasms, demonstrated the specificity and potential clinical utility of GATA3 across urothelial, mammary and cutaneous squamous lesions(1, 2) . This article is protected by copyright. All rights reserved.Citation
GATA3 shows differential immunohistochemical expression across thyroid and parathyroid lesions. 2014: HistopathologyJournal
HistopathologyDOI
10.1111/his.12388PubMed ID
24512009Type
ArticleLanguage
enISSN
1365-2559ae974a485f413a2113503eed53cd6c53
10.1111/his.12388
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