GATA3 shows differential immunohistochemical expression across thyroid and parathyroid lesions.

Abstract

Transcription factors have proved highly specific immunohistochemical markers e.g. TTF-1 (thyroid/lung) and CDX-2 (Gastro-intestinal). GATA3 is a transcription factor which is functionally involved with the development of breast, urothelial, epidermal, T lymphocyte and parathyroid tissue. Recent studies of GATA3 immunoprofile, including that by Miettinen et al. across 2040 epithelial malignancies and 460 mesenchymal or neuroectodermal neoplasms, demonstrated the specificity and potential clinical utility of GATA3 across urothelial, mammary and cutaneous squamous lesions(1, 2) . This article is protected by copyright. All rights reserved.