Methylation profiling and evaluation of demethylating therapy in renal cell carcinoma.
Authors
Ricketts, CMorris, M
Gentle, D
Shuib, S
Brown, Michael D
Clarke, Noel W
Wei, W
Nathan, P
Latif, F
Maher, E
Issue Date
2013
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Show full item recordAbstract
Despite therapeutic advances in targeted therapy, metastatic renal cell carcinoma (RCC) remains incurable for the vast majority of patients. Key molecular events in the pathogenesis of RCC include inactivation of the VHL tumour suppressor gene (TSG), inactivation of chromosome 3p TSGs implicated in chromatin modification and remodelling and de novo tumour-specific promoter methylation of renal TSGs. In the light of these observations it can be proposed that, as in some haematological malignancies, demethylating agents such as azacitidine might be beneficial for the treatment of advanced RCC.Citation
Methylation profiling and evaluation of demethylating therapy in renal cell carcinoma. 2013, 5 (1):16 Clin EpigeneticsJournal
Clinical EpigeneticsDOI
10.1186/1868-7083-5-16PubMed ID
24034811Type
ArticleLanguage
enISSN
1868-7075ae974a485f413a2113503eed53cd6c53
10.1186/1868-7083-5-16
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