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    Brostallicin versus doxorubicin as first-line chemotherapy in patients with advanced or metastatic soft tissue sarcoma: an European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group randomised phase II and pharmacogenetic study.

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    Authors
    Gelderblom, H
    Blay, J
    Seddon, B
    Leahy, Michael G
    Ray-Coquard, I
    Sleijfer, S
    Kerst, J M
    Rutkowski, P
    Bauer, S
    Ouali, M
    Marreaud, S
    van der Straaten, R
    Guchelaar, H
    Weitman, S
    Hogendoorn, P
    Hohenberger, P
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    Issue Date
    2014-01
    
    Metadata
    Show full item record
    Abstract
    Brostallicin is a DNA minor groove binder that has shown activity in patients with soft tissue sarcoma (STS) failing first-line therapy. The present study assessed the safety and efficacy of first-line brostallicin in patients with advanced or metastatic STS >60 years or not fit enough to receive combination chemotherapy. A prospective explorative pharmacogenetic analysis was undertaken in parallel.
    Citation
    Brostallicin versus doxorubicin as first-line chemotherapy in patients with advanced or metastatic soft tissue sarcoma: an European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group randomised phase II and pharmacogenetic study. 2014, 50 (2):388-96 Eur J Cancer
    Journal
    European Journal of Cancer
    URI
    http://hdl.handle.net/10541/313657
    DOI
    10.1016/j.ejca.2013.10.002
    PubMed ID
    24215845
    Type
    Article
    Language
    en
    ISSN
    1879-0852
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ejca.2013.10.002
    Scopus Count
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