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    A randomized study of interferon α-2b versus no treatment as consolidation after high dose therapy and autologous stem cell transplantation for patients with relapsed lymphoma.

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    Authors
    Bosly, A
    Grigg, A
    Holte, H
    Gisselbrecht, C
    Radford, John A
    Rossi, A
    Lopez-Guillermo, A
    Trneny, M
    Sebban, C
    Hagberg, H
    Leal da Costa, F
    Colombat, P
    Bron, D
    Coiffier, B
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    Issue Date
    2013
    
    Metadata
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    Abstract
    Patients with lymphoma who have experienced a first relapse or progression and have disease deemed sensitive to salvage chemotherapy nevertheless have a high likelihood of having a second relapse. To decrease the likelihood of a second relapse after high-dose therapy (HDT) and autologous stem cell transplantation (ASCT), interferon (IFN) α-2b was given in a prospective randomized international trial. Methods. In this trial, 221 patients with varying histologic diagnoses (8 small lymphocytic, 37 follicular, 9 mantle, 90 diffuse large B-cell, 20 peripheral T-cell, 3 high-grade B-cell non-Hodgkin lymphoma, and 54 Hodgkin lymphoma) were randomly assigned to receive no further treatment (arm A: 117 patients) or IFNα-2b, 3 MU three times weekly, for 18 months (arm B: 104 patients). Results. In arm B, 21 patients (20%) did not receive IFNα-2b because of early progression or absence of hematologic recovery, 29 patients (28%) completed the 18 months of treatment, and 54 patients (52%) interrupted treatment because of progression (23%) or toxicity (29%). Event-free survival and overall survival were not different between the two arms on an intent-to-treat analysis and also if analysis was restricted to patients who were alive and had not experienced disease progression three months after transplantation. The study was not sufficiently powered to evaluate effects in histologic subtypes. Conclusion. In this trial, post-autograft IFNα-2b did not improve outcomes in a heterogeneous group of patients with lymphoma.
    Citation
    A randomized study of interferon α-2b versus no treatment as consolidation after high dose therapy and autologous stem cell transplantation for patients with relapsed lymphoma. 2013, 18 (11):1189 Oncologist
    Journal
    The Oncologist
    URI
    http://hdl.handle.net/10541/312806
    DOI
    10.1634/theoncologist.2013-0223
    PubMed ID
    24105750
    Type
    Article
    Language
    en
    ISSN
    1549-490X
    ae974a485f413a2113503eed53cd6c53
    10.1634/theoncologist.2013-0223
    Scopus Count
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