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    Endothelial caveolin-1 plays a major role in the development of atherosclerosis.

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    Authors
    Pavlides, Stephanos
    Gutierrez-Pajares, J
    Iturrieta, J
    Lisanti, Michael P
    Frank, P
    Issue Date
    2014-01-07
    
    Metadata
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    Abstract
    Clinical studies have established the important impact of atherosclerotic disease in Western societies. This disease is characterized by the accumulation of lipids and the migration of various cell types in the sub-endothelial space of blood vessels. As demonstrated by many studies, endothelial cells play an essential role in the development of this disease. The endothelium acts as a gatekeeper of blood vessel integrity and cardiovascular health status. For instance, the transfer of lipids via the transport of lipoproteins in the arterial intima is believed to be mediated by endothelial cells through a process termed transcytosis. In addition, lipoproteins that accumulate in the sub-endothelial space may also be modified, in a process that can direct the activation of endothelial cells. These steps are essential for the initiation of an atherosclerotic plaque and may be mediated, at least in part, by caveolae and their associated protein caveolin-1. In the present study, we evaluate the role of caveolin-1/caveolae in the regulation of these two steps in endothelial cells. Our data clearly demonstrate that caveolin-1 is involved in the regulation of lipoprotein transcytosis across endothelial cells and in the regulation of vascular inflammation.
    Citation
    Endothelial caveolin-1 plays a major role in the development of atherosclerosis. 2014: Cell Tissue Res
    Journal
    Cell and Tissue Research
    URI
    http://hdl.handle.net/10541/312450
    DOI
    10.1007/s00441-013-1767-7
    PubMed ID
    24390341
    Type
    Article
    Language
    en
    ISSN
    1432-0878
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00441-013-1767-7
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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