A bias-free, automated planning tool for technique comparison in radiotherapy - application to nasopharyngeal carcinoma treatments.
AbstractIn this study a novel, user-independent automated planning technique was developed to objectively compare volumetric modulated arc therapy (VMAT) and intensity-modulated radiotherapy (IMRT) for nasopharyngeal carcinoma planning, and to determine which technique offers a greater benefit for parotid-sparing and dose escalation strategies. Ten patients were investigated, with a standard prescription of three dose levels to the target volumes (70, 63, and 56 Gy), using a simultaneous integrated boost in 33 fractions. The automated tool was used to investigate three planning strategies with both IMRT and VMAT: clinically acceptable plan creation, parotid dose sparing, and dose escalation. Clinically acceptable plans were achieved for all patients using both techniques. For parotid sparing, automated planning reduced the mean dose to a greater extent using VMAT rather than IMRT (17.0 Gy and 19.6 Gy, respectively, p < 0.01). For dose escalation to the mean of the main clinical target volume, neither VMAT nor IMRT offered a significant benefit over the other. The OAR-limiting prescriptions for VMAT ranged from 84-98 Gy, compared to 76-110 Gy for IMRT. Employing a user-independent planning technique, it was possible to objectively compare VMAT and IMRT for nasopharyngeal carcinoma treatment strategies. VMAT offers a parotid-sparing improvement, but no significant benefit was observed for dose escalation to the primary target.
CitationA bias-free, automated planning tool for technique comparison in radiotherapy - application to nasopharyngeal carcinoma treatments. 2014, 15 (1):4530 J Appl Clin Med Phys
JournalJournal of Applied Clinical Medical Physics
- <sup>18</sup> F-Fluoromisonidazole positron emission tomography/CT-guided volumetric-modulated arc therapy-based dose escalation for hypoxic subvolume in nasopharyngeal carcinomas: A feasibility study.
- Authors: Qiu J, Lv B, Fu M, Wang X, Zheng X, Zhuo W
- Issue date: 2017 Dec
- Dual arc volumetric-modulated arc radiotherapy (VMAT) of nasopharyngeal carcinomas: a simultaneous integrated boost treatment plan comparison with intensity-modulated radiotherapies and single arc VMAT.
- Authors: Lee TF, Ting HM, Chao PJ, Fang FM
- Issue date: 2012 Apr
- Volumetric modulated arc therapy for nasopharyngeal carcinoma: a dosimetric comparison with TomoTherapy and step-and-shoot IMRT.
- Authors: Lu SH, Cheng JC, Kuo SH, Lee JJ, Chen LH, Wu JK, Chen YH, Chen WY, Wen SY, Chong FC, Wu CJ, Wang CW
- Issue date: 2012 Sep
- Volumetric-modulated arc therapy in head and neck radiotherapy: a planning comparison using simultaneous integrated boost for nasopharynx and oropharynx carcinoma.
- Authors: Johnston M, Clifford S, Bromley R, Back M, Oliver L, Eade T
- Issue date: 2011 Oct
- Intensity-modulated radiotherapy in nasopharyngeal carcinoma: dosimetric advantage over conventional plans and feasibility of dose escalation.
- Authors: Kam MK, Chau RM, Suen J, Choi PH, Teo PM
- Issue date: 2003 May 1