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    How can we optimise concurrent chemoradiotherapy for inoperable stage III non-small cell lung cancer?

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    Authors
    Bayman, Neil A
    Blackhall, Fiona H
    McCloskey, Paula
    Taylor, P
    Faivre-Finn, Corinne
    Affiliation
    The Christie NHS Foundation Trust, Withington, Manchester, M20 4BX, UK
    Issue Date
    2014-02
    
    Metadata
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    Abstract
    Latest evidence sets a clear mandate for concurrent chemoradiotherapy as the current standard of care for inoperable stage III non small cell lung cancer patients with good performance status and minimal co-morbidities. However, a survival plateau has been reached, with disappointing results from dose escalation studies using conventional fractionation and studies investigating the addition of systemic doses of chemotherapy delivered before or after concurrent chemoradiotherapy. A review was carried out to address three questions considered fundamental to improving outcome in patients with stage III non-small cell lung cancer: It is clear that further improvement in outcome for these patients will be determined by better local control and by reducing the risk of distant recurrence. Given the technological advances in radiotherapy planning and delivery in recent years plus the abundance of novel targeted therapies exploiting critical oncogenic pathways, further advances in combined drug-radiation treatment for lung cancer seem highly possible.
    Citation
    How can we optimise concurrent chemoradiotherapy for inoperable stage III non-small cell lung cancer? 2014, 83 (2):117-25 Lung Cancer
    Journal
    Lung Cancer
    URI
    http://hdl.handle.net/10541/312425
    DOI
    10.1016/j.lungcan.2013.11.017
    PubMed ID
    24373738
    Type
    Article
    Language
    en
    ISSN
    1872-8332
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.lungcan.2013.11.017
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