• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjectsProfilesView

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Copeptin as a marker for arginine-vasopressin/antidiuretic hormone secretion in the diagnosis of paraneoplastic syndrome of inappropriate ADH secretion.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Wuttke, A
    Dixit, Kashinath C S
    Szinnai, G
    Werth, S
    Haagen, U
    Christ-Crain, M
    Morgenthaler, N
    Brabant, Georg E
    Issue Date
    2013-12
    
    Metadata
    Show full item record
    Abstract
    Direct measurement of arginine-vasopressin/antidiuretic hormone (AVP/ADH) concentrations is not included in the standard diagnostic procedures for paraneoplastic syndrome of inappropriate ADH secretion (SIADH). Here, we evaluate the potential of copeptin measurement as a surrogate marker of AVP/ADH secretion for the direct diagnosis of suspected SIADH in cancer patients. Forty-six unselected cancer patients with serum sodium concentrations permanently below 135 mmol/L were included in this study. We compared standard diagnostic criteria for SIADH to the measurement of plasma copeptin in relation to osmolality. Normative data for comparison were constructed from 24 healthy controls studied under basal conditions, experimental dehydration, and hypotonic hypervolemia as well as from 222 hospital patients with no suspicion of an altered ADH regulation. Log transformation of copeptin revealed a linear relationship to plasma osmolality in the controls (R = 0.495, p < 0.001). Compared to these normative data, copeptin levels in most cancer patients were inappropriately high for plasma osmolality and were not significantly correlated. These results, suggestive for paraneoplastic SIADH, could be confirmed by conventional diagnostic procedures for SIADH. Current strategies to diagnose SIADH are difficult to perform under outpatients conditions. Our approach allows screening from a single plasma sample for true paraneoplastic ADH oversecretion and thus rapid selection for a specific therapy with an AVP receptor antagonist.
    Citation
    Copeptin as a marker for arginine-vasopressin/antidiuretic hormone secretion in the diagnosis of paraneoplastic syndrome of inappropriate ADH secretion. 2013, 44 (3):744-9 Endocrine
    Journal
    Endocrine
    URI
    http://hdl.handle.net/10541/312406
    DOI
    10.1007/s12020-013-9919-9
    PubMed ID
    23479045
    Type
    Article
    Language
    en
    ISSN
    1559-0100
    ae974a485f413a2113503eed53cd6c53
    10.1007/s12020-013-9919-9
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • An abnormal apelin/vasopressin balance may contribute to water retention in patients with the syndrome of inappropriate antidiuretic hormone (SIADH) and heart failure.
    • Authors: Blanchard A, Steichen O, De Mota N, Curis E, Gauci C, Frank M, Wuerzner G, Kamenicky P, Passeron A, Azizi M, Llorens-Cortes C
    • Issue date: 2013 May
    • A copeptin-based classification of the osmoregulatory defects in the syndrome of inappropriate antidiuresis.
    • Authors: Fenske W, Sandner B, Christ-Crain M
    • Issue date: 2016 Mar
    • Use of Copeptin Levels to Predict the Resolution of Transient Postoperative SIADH.
    • Authors: Jones B, Corredor M, Lteif A, Pittock S, Bornhorst J, Creo A
    • Issue date: 2020
    • A copeptin-based classification of the osmoregulatory defects in the syndrome of inappropriate antidiuresis.
    • Authors: Fenske WK, Christ-Crain M, Hörning A, Simet J, Szinnai G, Fassnacht M, Rutishauser J, Bichet DG, Störk S, Allolio B
    • Issue date: 2014 Oct
    • Hypothalamic-pituitary-adrenal axis and interleukin-6 activity in children with head trauma and syndrome of inappropriate secretion of antidiuretic hormone.
    • Authors: Gionis D, Ilias I, Moustaki M, Mantzos E, Papadatos I, Koutras DA, Mastorakos G
    • Issue date: 2003 Jan
    DSpace software (copyright © 2002 - 2025)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.