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    Poly(ADP-ribosyl)ation in regulation of chromatin structure and the DNA damage response.

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    Authors
    Tallis, Michael
    Morra, Rosa
    Barkauskaite, Eva
    Ahel, Ivan
    Affiliation
    Cancer Research UK, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester, M20 4BX, UK.
    Issue Date
    2013-10-27
    
    Metadata
    Show full item record
    Abstract
    Poly(ADP-ribose) (PAR) is a post-translational modification of proteins and is synthesised by PAR polymerases (PARPs), which have long been associated with the coordination of the cellular response to DNA damage, amongst other processes. Binding of some PARPs such as PARP1 to broken DNA induces a substantial wave of PARylation, which results in significant re-structuring of the chromatin microenvironment through modification of chromatin-associated proteins and recruitment of chromatin-modifying proteins. Similarly, other DNA damage response proteins are recruited to the damaged sites via PAR-specific binding modules, and in this way, PAR mediates not only local chromatin architecture but also DNA repair. Here, we discuss the expanding role of PAR in the DNA damage response, with particular focus on chromatin regulation.
    Citation
    Poly(ADP-ribosyl)ation in regulation of chromatin structure and the DNA damage response. 2013: Chromosoma
    Journal
    Chromosoma
    URI
    http://hdl.handle.net/10541/308840
    DOI
    10.1007/s00412-013-0442-9
    PubMed ID
    24162931
    Type
    Article
    Language
    en
    ISSN
    1432-0886
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00412-013-0442-9
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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