Poly(ADP-ribosyl)ation in regulation of chromatin structure and the DNA damage response.
Affiliation
Cancer Research UK, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester, M20 4BX, UK.Issue Date
2013-10-27
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Poly(ADP-ribose) (PAR) is a post-translational modification of proteins and is synthesised by PAR polymerases (PARPs), which have long been associated with the coordination of the cellular response to DNA damage, amongst other processes. Binding of some PARPs such as PARP1 to broken DNA induces a substantial wave of PARylation, which results in significant re-structuring of the chromatin microenvironment through modification of chromatin-associated proteins and recruitment of chromatin-modifying proteins. Similarly, other DNA damage response proteins are recruited to the damaged sites via PAR-specific binding modules, and in this way, PAR mediates not only local chromatin architecture but also DNA repair. Here, we discuss the expanding role of PAR in the DNA damage response, with particular focus on chromatin regulation.Citation
Poly(ADP-ribosyl)ation in regulation of chromatin structure and the DNA damage response. 2013: ChromosomaJournal
ChromosomaDOI
10.1007/s00412-013-0442-9PubMed ID
24162931Type
ArticleLanguage
enISSN
1432-0886ae974a485f413a2113503eed53cd6c53
10.1007/s00412-013-0442-9
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