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    Interventions for the treatment of Paget's disease of the vulva.

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    Authors
    Edey, K
    Allan, Ernest
    Murdoch, J
    Cooper, S
    Bryant, A
    Issue Date
    2013
    
    Metadata
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    Abstract
    Extra-mammary Paget's disease is a rare form of superficial skin cancer. The most common site of involvement is the vulva. It is seen mainly in postmenopausal white women. Paget's disease of the vulva often spreads in an occult fashion, with margins extending beyond the apparent edges of the lesion. There is a range of interventions from surgical to non-invasive techniques or treatments. The challenges of interventions are to remove or treat disease that may not be visible, without overtreatment and with minimisation of morbidity from radical surgery. There is little consensus regarding treatment. Surgery, by default, is the most common treatment, but it is challenging to excise the disease adequately, and recurrence is common, leading to repeated operations, and destruction of anatomy. Alternative treatments of photodynamic therapy, laser therapy, radiotherapy, topical treatments or even chemotherapy have been mooted, and it is important to evaluate the available evidence. It is essential to assess whether newer cell-specific treatments, such as photodynamic therapy and imiquimod, can reduce the need for radical surgery.
    Citation
    Interventions for the treatment of Paget's disease of the vulva. 2013, 10:CD009245 Cochrane Database Syst Rev
    Journal
    The Cochrane Database of Systematic Reviews
    URI
    http://hdl.handle.net/10541/308817
    DOI
    10.1002/14651858.CD009245.pub2
    PubMed ID
    24163070
    Type
    Article
    Language
    en
    ISSN
    1469-493X
    ae974a485f413a2113503eed53cd6c53
    10.1002/14651858.CD009245.pub2
    Scopus Count
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