Method validation of circulating tumour cell enumeration at low cell counts.
Krebs, Matthew G
AffiliationClinical and Experimental Pharmacology Group, Paterson Institute for Cancer Research, Manchester Cancer Research Centre, University of Manchester, Manchester M20 4BX.
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AbstractCirculating tumour cells (CTC) are receiving increasing attention as prognostic, predictive and pharmacodynamic biomarkers in cancer patients. However, their clinical significance can be dependent on an accurate determination of CTC around cut-off values at low cell counts (<10 cells/7.5 ml). Consequently, we have conducted method validation of the CellSearch™ system focusing on clinical samples containing CTC in the cut-off region.
CitationMethod validation of circulating tumour cell enumeration at low cell counts. 2013, 13:415 BMC Cancer