The prognostic significance of the biomarker p16 in oropharyngeal squamous cell carcinoma.
Authors
Oguejiofor, Kenneth KHall, J S
Mani, Navin
Douglas, C
Slevin, Nicholas J
Homer, J
Hall, G
West, Catharine M L
Affiliation
Translational Radiobiology Group, Institute of Cancer Sciences, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.Issue Date
2013-11
Metadata
Show full item recordAbstract
There is an increasing incidence of human papillomavirus (HPV)-positive oropharyngeal squamous cell cancers (OPSCC) mostly associated with favourable outcomes. p16 immunohistochemistry is a surrogate marker for HPV positivity in OPSCC. The prognostic strength of p16 over traditional prognostic factors is not fully characterised. In this study, we evaluated the clinical and demographic differences between p16-positive and -negative OPSCC and characterised its prognostic strength versus traditional prognostic factors.Citation
The prognostic significance of the biomarker p16 in oropharyngeal squamous cell carcinoma. 2013, 25 (11):630-8 Clin OncolJournal
Clinical OncologyDOI
10.1016/j.clon.2013.07.003PubMed ID
23916365Type
ArticleLanguage
enISSN
1433-2981ae974a485f413a2113503eed53cd6c53
10.1016/j.clon.2013.07.003