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    A phase 1 trial of intravenous 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) in patients with advanced solid tumours.

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    Authors
    Horsley, Laura
    Cummings, Jeffrey
    Middleton, M
    Ward, Timothy H
    Backen, Alison C
    Clamp, Andrew R
    Dawson, Martin J
    Farmer, H
    Fisher, N
    Halbert, G
    Halford, S
    Harris, A
    Hasan, Jurjees
    Hogg, P
    Kumaran, Gireesh C
    Little, R
    Parker, G
    Potter, Paula
    Saunders, Mark P
    Roberts, C
    Shaw, Danielle
    Smith, Nigel K
    Smythe, J
    Taylor, A
    Turner, H
    Watson, Y
    Dive, Caroline
    Jayson, Gordon C
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    Affiliation
    Institute for Cancer Studies Christie Hospital NHS Foundation Trust, Wilmslow Road, Withington, Manchester, M20 4BX, UK.
    Issue Date
    2013-12
    
    Metadata
    Show full item record
    Abstract
    4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) is a water-soluble mitochondrial toxin that binds to adenine nucleotide translocase in the inner mitochondrial membrane, thereby targeting cell proliferation. This phase 1 study investigated safety, dose-limiting toxicities (DLTs), maximum tolerated dose (MTD) and pharmacokinetics (PK) of GSAO as a daily 1-h infusion for 5 days a week for 2 weeks in every three. Pharmacodynamics of GSAO was evaluated by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and circulating markers of angiogenesis.
    Citation
    A phase 1 trial of intravenous 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) in patients with advanced solid tumours. 2013, 72 (6):1343-52 Cancer Chemother Pharmacol
    Journal
    Cancer Chemotherapy and Pharmacology
    URI
    http://hdl.handle.net/10541/308799
    DOI
    10.1007/s00280-013-2320-9
    PubMed ID
    24141375
    Type
    Article
    Language
    en
    ISSN
    1432-0843
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00280-013-2320-9
    Scopus Count
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