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    Nuclear phosphoinositides and their impact on nuclear functions.

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    Authors
    Shah, Zahid H
    Jones, David R
    Sommer, Lilly
    Foulger, Rebecca
    Bultsma, Yvette
    D'Santos, C
    Divecha, Nullin
    Affiliation
    Cancer Research UK Inositide Laboratory, Paterson Institute for Cancer Research, Wilmslow Road, Manchester, M20 4BX, UK.
    Issue Date
    2013-09-24
    
    Metadata
    Show full item record
    Abstract
    Polyphosphoinositides (PPIn) are important lipid molecules whose levels are deregulated in human diseases such as cancer, neurodegenerative and in metabolic syndromes. PPIn are synthesised and degraded by an array of kinases, phosphatases and lipases which are localised to various subcellular compartments and are subject to regulation in response to both extra- and intracellular cues. Changes in the activities of enzymes that metabolise PPIn lead to changes in the profiles of PPIn in different sub-cellular compartments. Understanding how subcellular PPIn are regulated and how they impact on downstream signaling is critical to understand their roles in human diseases. PPIn are present in the nucleus, and their levels are changed in response to various stimuli, suggesting that they may serve to regulate specific nuclear functions. However, the lack of nuclear downstream targets has hindered the definition of which pathways nuclear PPIn impact on. Over recent years targeted and global proteomic studies have identified a plethora of potential PPIn interacting proteins involved in many aspects of transcription, chromatin remodeling and mRNA maturation suggesting that PPIn signaling within the nucleus represents a largely unexplored novel layer of complexity in the regulation of nuclear functions. This article is protected by copyright. All rights reserved.
    Citation
    Nuclear phosphoinositides and their impact on nuclear functions. 2013: FEBS J
    Journal
    FEBS Journal
    URI
    http://hdl.handle.net/10541/304739
    DOI
    10.1111/febs.12543
    PubMed ID
    24112514
    Type
    Article
    Language
    en
    ISSN
    1742-4658
    ae974a485f413a2113503eed53cd6c53
    10.1111/febs.12543
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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