Molecular and cellular processes underlying the hallmarks of head and neck cancer.
AffiliationUniversity Department of Otolaryngology-Head and Neck Surgery, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK. firstname.lastname@example.org
MetadataShow full item record
AbstractThe hallmarks of cancer were updated by Hanahan and Weinberg in 2011. Here we discuss the updated hallmarks in relation to what is known of the molecular and cellular processes underlying the development of head and neck squamous cell carcinoma (HNSCC). Several mechanisms are described, and recent surveys of HNSCC suggest a limited number of mutations, from which more mechanisms may emerge. There are also epigenetic changes to the control of normal processes. More than one mechanism underlies each hallmark. Processes essential to the development of HNSCC need not be essential to the proliferation of the fully developed tumour. Attention is paid to the emerging hallmarks, deregulation of cellular energy metabolism and evasion of immune destruction, and enabling characteristics, genome instability and mutation and tumour-promoting inflammation. HNSCC may adapt to hypoxia, suppress HLA expression, and express Toll-like receptors to facilitate inflammation, which support the proliferation of the tumour.
CitationMolecular and cellular processes underlying the hallmarks of head and neck cancer. 2013, 270 (10):2585-93 Eur Arch Otorhinolaryngol
JournalEuropean Archives of Oto-Rhino-Laryngology
- Promoter methylation of MGMT, MLH1 and RASSF1A tumor suppressor genes in head and neck squamous cell carcinoma: pharmacological genome demethylation reduces proliferation of head and neck squamous carcinoma cells.
- Authors: Koutsimpelas D, Pongsapich W, Heinrich U, Mann S, Mann WJ, Brieger J
- Issue date: 2012 Apr
- Loss of Mitochondrial Tumor Suppressor Genes Expression Is Associated with Unfavorable Clinical Outcome in Head and Neck Squamous Cell Carcinoma: Data from Retrospective Study.
- Authors: Mahjabeen I, Kayani MA
- Issue date: 2016
- Toll-like receptor modulation in head and neck cancer.
- Authors: Pries R, Wulff S, Wollenberg B
- Issue date: 2008
- γ-Secretase inhibitor reduces immunosuppressive cells and enhances tumour immunity in head and neck squamous cell carcinoma.
- Authors: Mao L, Zhao ZL, Yu GT, Wu L, Deng WW, Li YC, Liu JF, Bu LL, Liu B, Kulkarni AB, Zhang WF, Zhang L, Sun ZJ
- Issue date: 2018 Mar 1
- Blockade of adenosine A2A receptor enhances CD8<sup>+</sup> T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma.
- Authors: Ma SR, Deng WW, Liu JF, Mao L, Yu GT, Bu LL, Kulkarni AB, Zhang WF, Sun ZJ
- Issue date: 2017 Jun 7