• Login
    View Item 
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    •   Home
    • The Christie Research Publications Repository
    • All Christie Publications
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    Molecular and cellular processes underlying the hallmarks of head and neck cancer.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Bernstein, J
    Bernstein, C
    West, Catharine M L
    Homer, J
    Affiliation
    University Department of Otolaryngology-Head and Neck Surgery, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK. jonathan.bernstein@doctors.org.uk
    Issue Date
    2013-09
    
    Metadata
    Show full item record
    Abstract
    The hallmarks of cancer were updated by Hanahan and Weinberg in 2011. Here we discuss the updated hallmarks in relation to what is known of the molecular and cellular processes underlying the development of head and neck squamous cell carcinoma (HNSCC). Several mechanisms are described, and recent surveys of HNSCC suggest a limited number of mutations, from which more mechanisms may emerge. There are also epigenetic changes to the control of normal processes. More than one mechanism underlies each hallmark. Processes essential to the development of HNSCC need not be essential to the proliferation of the fully developed tumour. Attention is paid to the emerging hallmarks, deregulation of cellular energy metabolism and evasion of immune destruction, and enabling characteristics, genome instability and mutation and tumour-promoting inflammation. HNSCC may adapt to hypoxia, suppress HLA expression, and express Toll-like receptors to facilitate inflammation, which support the proliferation of the tumour.
    Citation
    Molecular and cellular processes underlying the hallmarks of head and neck cancer. 2013, 270 (10):2585-93 Eur Arch Otorhinolaryngol
    Journal
    European Archives of Oto-Rhino-Laryngology
    URI
    http://hdl.handle.net/10541/304723
    DOI
    10.1007/s00405-012-2323-x
    PubMed ID
    23263268
    Type
    Article
    Language
    en
    ISSN
    1434-4726
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00405-012-2323-x
    Scopus Count
    Collections
    All Christie Publications

    entitlement

    Related articles

    • Promoter methylation of MGMT, MLH1 and RASSF1A tumor suppressor genes in head and neck squamous cell carcinoma: pharmacological genome demethylation reduces proliferation of head and neck squamous carcinoma cells.
    • Authors: Koutsimpelas D, Pongsapich W, Heinrich U, Mann S, Mann WJ, Brieger J
    • Issue date: 2012 Apr
    • Loss of Mitochondrial Tumor Suppressor Genes Expression Is Associated with Unfavorable Clinical Outcome in Head and Neck Squamous Cell Carcinoma: Data from Retrospective Study.
    • Authors: Mahjabeen I, Kayani MA
    • Issue date: 2016
    • Toll-like receptor modulation in head and neck cancer.
    • Authors: Pries R, Wulff S, Wollenberg B
    • Issue date: 2008
    • γ-Secretase inhibitor reduces immunosuppressive cells and enhances tumour immunity in head and neck squamous cell carcinoma.
    • Authors: Mao L, Zhao ZL, Yu GT, Wu L, Deng WW, Li YC, Liu JF, Bu LL, Liu B, Kulkarni AB, Zhang WF, Zhang L, Sun ZJ
    • Issue date: 2018 Mar 1
    • Blockade of adenosine A2A receptor enhances CD8(+) T cells response and decreases regulatory T cells in head and neck squamous cell carcinoma.
    • Authors: Ma SR, Deng WW, Liu JF, Mao L, Yu GT, Bu LL, Kulkarni AB, Zhang WF, Sun ZJ
    • Issue date: 2017 Jun 7
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.