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    Immunogenic potential of irradiated lymphoma cells is enhanced by adjuvant immunotherapy and modulation of local macrophage populations.

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    Authors
    Honeychurch, Jamie
    Melis, Monique H M
    Dovedi, Simon J
    Mu, L
    Illidge, Timothy M
    Affiliation
    Targeted Therapy Group, Institute of Cancer Sciences, University of Manchester, Manchester Academic Health Sciences Centre, Paterson Institute for Cancer Research, Manchester, UK.
    Issue Date
    2013-09
    
    Metadata
    Show full item record
    Abstract
    The aim of this study was to assess the immunogenic potential of irradiated lymphoma cells in vivo and determine whether immunogenicity can be enhanced by modulation of the host immune system. Syngeneic murine lymphoma models irradiated ex vivo were used as an orthotopic cellular vaccination prior to challenge with viable tumor cells. We demonstrate that irradiated lymphoma cells are poorly immunogenic and that protective anti-tumor CD8 T-cell responses require the addition of immunostimulatory monoclonal antibody as an immune adjuvant, and increased frequency of antigen exposure by multiple vaccinations. Furthermore, we show the potential importance of macrophages in regulating immunogenicity of irradiated lymphoma cells and demonstrate that depletion of macrophages using clodronate-encapsulated liposomes considerably enhances primary vaccination efficacy in the presence of adjuvant anti-CD40 antibody. Our results demonstrate that the immunogenic potential of poorly immunogenic lymphoma cells dying after radiation therapy can be improved by modulation of the host immune system.
    Citation
    Immunogenic potential of irradiated lymphoma cells is enhanced by adjuvant immunotherapy and modulation of local macrophage populations. 2013, 54 (9):2008-15 Leuk Lymphoma
    Journal
    Leukemia & Lymphoma
    URI
    http://hdl.handle.net/10541/304715
    DOI
    10.3109/10428194.2013.769219
    PubMed ID
    23339450
    Type
    Article
    Language
    en
    ISSN
    1029-2403
    ae974a485f413a2113503eed53cd6c53
    10.3109/10428194.2013.769219
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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