Chemically facilitating the generation of diagnostic ions from SUMO(2/3) remnant isopeptides.

Authors
Chicooree, Navin
Griffiths, John R
Connolly, Yvonne
Smith, Duncan L
Affiliation
Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester, M20 4BX, UK; School of Chemistry, University of Manchester, Brunswick Street, Manchester, M13 9SU, UK.
Issue Date
2013-09-30

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Abstract
Mapping sites of wild-type SUMO modification is a challenging endeavour. Here we postulate that a combination of chemical derivatistation and collision-induced dissociation (CID) could be used to generate SUMO remnant diagnostic ions to aid both detection of these isopeptides and increase the analytical value of the product ion spectra required to characterize the nature and position of modification.
Citation
Chemically facilitating the generation of diagnostic ions from SUMO(2/3) remnant isopeptides. 2013, 27 (18):2108-14 Rapid Commun Mass Spectrom
Journal
Rapid Communications in Mass Spectrometry
URI
http://hdl.handle.net/10541/302284
DOI
10.1002/rcm.6670
PubMed ID
23943332
Type
Article
Language
en
ISSN
1097-0231
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