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dc.contributor.authorIvanov, S
dc.contributor.authorPanaccione, A
dc.contributor.authorNonaka, Daisuke
dc.contributor.authorPrasad, M
dc.contributor.authorBoyd, K
dc.contributor.authorBrown, B
dc.contributor.authorGuo, Y
dc.contributor.authorSewell, A
dc.contributor.authorYarbrough, W
dc.date.accessioned2013-09-25T13:38:14Z
dc.date.available2013-09-25T13:38:14Z
dc.date.issued2013-07-23
dc.identifier.citationDiagnostic SOX10 gene signatures in salivary adenoid cystic and breast basal-like carcinomas. 2013, 109 (2):444-51 Br J Canceren_GB
dc.identifier.issn1532-1827
dc.identifier.pmid23799842
dc.identifier.doi10.1038/bjc.2013.326
dc.identifier.urihttp://hdl.handle.net/10541/302281
dc.description.abstractSalivary adenoid cystic carcinoma (ACC) is an insidious slow-growing cancer with the propensity to recur and metastasise to distant sites. Basal-like breast carcinoma (BBC) is a molecular subtype that constitutes 15-20% of breast cancers, shares histological similarities and basal cell markers with ACC, lacks expression of ER (oestrogen receptor), PR (progesterone receptor), and HER2 (human epidermal growth factor receptor 2), and, similar to ACC, metastasises predominantly to the lung and brain. Both cancers lack targeted therapies owing to poor understanding of their molecular drivers.
dc.language.isoenen
dc.rightsArchived with thanks to British journal of canceren_GB
dc.titleDiagnostic SOX10 gene signatures in salivary adenoid cystic and breast basal-like carcinomas.en
dc.typeArticleen
dc.contributor.departmentSection of Otolaryngology, Department of Surgery, Yale School of Medicine, 800 Howard Avenue, New Haven, CT 06519-1369, USA.en_GB
dc.identifier.journalBritish Journal of Canceren_GB
html.description.abstractSalivary adenoid cystic carcinoma (ACC) is an insidious slow-growing cancer with the propensity to recur and metastasise to distant sites. Basal-like breast carcinoma (BBC) is a molecular subtype that constitutes 15-20% of breast cancers, shares histological similarities and basal cell markers with ACC, lacks expression of ER (oestrogen receptor), PR (progesterone receptor), and HER2 (human epidermal growth factor receptor 2), and, similar to ACC, metastasises predominantly to the lung and brain. Both cancers lack targeted therapies owing to poor understanding of their molecular drivers.


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