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    Diagnostic SOX10 gene signatures in salivary adenoid cystic and breast basal-like carcinomas.

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    Authors
    Ivanov, S
    Panaccione, A
    Nonaka, Daisuke
    Prasad, M
    Boyd, K
    Brown, B
    Guo, Y
    Sewell, A
    Yarbrough, W
    Affiliation
    Section of Otolaryngology, Department of Surgery, Yale School of Medicine, 800 Howard Avenue, New Haven, CT 06519-1369, USA.
    Issue Date
    2013-07-23
    
    Metadata
    Show full item record
    Abstract
    Salivary adenoid cystic carcinoma (ACC) is an insidious slow-growing cancer with the propensity to recur and metastasise to distant sites. Basal-like breast carcinoma (BBC) is a molecular subtype that constitutes 15-20% of breast cancers, shares histological similarities and basal cell markers with ACC, lacks expression of ER (oestrogen receptor), PR (progesterone receptor), and HER2 (human epidermal growth factor receptor 2), and, similar to ACC, metastasises predominantly to the lung and brain. Both cancers lack targeted therapies owing to poor understanding of their molecular drivers.
    Citation
    Diagnostic SOX10 gene signatures in salivary adenoid cystic and breast basal-like carcinomas. 2013, 109 (2):444-51 Br J Cancer
    Journal
    British Journal of Cancer
    URI
    http://hdl.handle.net/10541/302281
    DOI
    10.1038/bjc.2013.326
    PubMed ID
    23799842
    Type
    Article
    Language
    en
    ISSN
    1532-1827
    ae974a485f413a2113503eed53cd6c53
    10.1038/bjc.2013.326
    Scopus Count
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