PLK1 and YY1 interaction in follicular lymphoma is associated with unfavourable outcome.
dc.contributor.author | Sandison, H | |
dc.contributor.author | Usher, S | |
dc.contributor.author | Karimiani, E | |
dc.contributor.author | Ashton, Garry | |
dc.contributor.author | Menasce, Lia P | |
dc.contributor.author | Radford, John A | |
dc.contributor.author | Linton, Kim M | |
dc.contributor.author | Byers, R | |
dc.date.accessioned | 2013-09-25T11:45:19Z | |
dc.date.available | 2013-09-25T11:45:19Z | |
dc.date.issued | 2013-09 | |
dc.identifier.citation | PLK1 and YY1 interaction in follicular lymphoma is associated with unfavourable outcome. 2013, 66 (9):764-7 J Clin Pathol | en_GB |
dc.identifier.issn | 1472-4146 | |
dc.identifier.pmid | 23757039 | |
dc.identifier.doi | 10.1136/jclinpath-2013-201461 | |
dc.identifier.uri | http://hdl.handle.net/10541/302255 | |
dc.description.abstract | Ying Yang 1 (YY1) is a transcription factor involved in both proliferation and apoptosis. It is prognostic in follicular lymphoma (FL), increased protein levels being associated with favourable outcome. PLK1 is a critical regulator of mitosis, playing a role in spindle formation and in regulation of the G2/M cell cycle checkpoint. PLK1 phosphorylates YY1 at the G2/M checkpoint with activation of YY1 and resultant progression from G2 into mitosis. | |
dc.language.iso | en | en |
dc.rights | Archived with thanks to Journal of clinical pathology | en_GB |
dc.title | PLK1 and YY1 interaction in follicular lymphoma is associated with unfavourable outcome. | en |
dc.type | Article | en |
dc.contributor.department | The Medical School, The University of Manchester, , Manchester, Greater Manchester, UK. | en_GB |
dc.identifier.journal | Journal of Clinical Pathology | en_GB |
html.description.abstract | Ying Yang 1 (YY1) is a transcription factor involved in both proliferation and apoptosis. It is prognostic in follicular lymphoma (FL), increased protein levels being associated with favourable outcome. PLK1 is a critical regulator of mitosis, playing a role in spindle formation and in regulation of the G2/M cell cycle checkpoint. PLK1 phosphorylates YY1 at the G2/M checkpoint with activation of YY1 and resultant progression from G2 into mitosis. |