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dc.contributor.authorSandison, H
dc.contributor.authorUsher, S
dc.contributor.authorKarimiani, E
dc.contributor.authorAshton, Garry
dc.contributor.authorMenasce, Lia P
dc.contributor.authorRadford, John A
dc.contributor.authorLinton, Kim M
dc.contributor.authorByers, R
dc.date.accessioned2013-09-25T11:45:19Z
dc.date.available2013-09-25T11:45:19Z
dc.date.issued2013-09
dc.identifier.citationPLK1 and YY1 interaction in follicular lymphoma is associated with unfavourable outcome. 2013, 66 (9):764-7 J Clin Patholen_GB
dc.identifier.issn1472-4146
dc.identifier.pmid23757039
dc.identifier.doi10.1136/jclinpath-2013-201461
dc.identifier.urihttp://hdl.handle.net/10541/302255
dc.description.abstractYing Yang 1 (YY1) is a transcription factor involved in both proliferation and apoptosis. It is prognostic in follicular lymphoma (FL), increased protein levels being associated with favourable outcome. PLK1 is a critical regulator of mitosis, playing a role in spindle formation and in regulation of the G2/M cell cycle checkpoint. PLK1 phosphorylates YY1 at the G2/M checkpoint with activation of YY1 and resultant progression from G2 into mitosis.
dc.language.isoenen
dc.rightsArchived with thanks to Journal of clinical pathologyen_GB
dc.titlePLK1 and YY1 interaction in follicular lymphoma is associated with unfavourable outcome.en
dc.typeArticleen
dc.contributor.departmentThe Medical School, The University of Manchester, , Manchester, Greater Manchester, UK.en_GB
dc.identifier.journalJournal of Clinical Pathologyen_GB
html.description.abstractYing Yang 1 (YY1) is a transcription factor involved in both proliferation and apoptosis. It is prognostic in follicular lymphoma (FL), increased protein levels being associated with favourable outcome. PLK1 is a critical regulator of mitosis, playing a role in spindle formation and in regulation of the G2/M cell cycle checkpoint. PLK1 phosphorylates YY1 at the G2/M checkpoint with activation of YY1 and resultant progression from G2 into mitosis.


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