PLK1 and YY1 interaction in follicular lymphoma is associated with unfavourable outcome.
Authors
Sandison, HUsher, S
Karimiani, E
Ashton, Garry
Menasce, Lia P
Radford, John A
Linton, Kim M
Byers, R
Affiliation
The Medical School, The University of Manchester, , Manchester, Greater Manchester, UK.Issue Date
2013-09
Metadata
Show full item recordAbstract
Ying Yang 1 (YY1) is a transcription factor involved in both proliferation and apoptosis. It is prognostic in follicular lymphoma (FL), increased protein levels being associated with favourable outcome. PLK1 is a critical regulator of mitosis, playing a role in spindle formation and in regulation of the G2/M cell cycle checkpoint. PLK1 phosphorylates YY1 at the G2/M checkpoint with activation of YY1 and resultant progression from G2 into mitosis.Citation
PLK1 and YY1 interaction in follicular lymphoma is associated with unfavourable outcome. 2013, 66 (9):764-7 J Clin PatholJournal
Journal of Clinical PathologyDOI
10.1136/jclinpath-2013-201461PubMed ID
23757039Type
ArticleLanguage
enISSN
1472-4146ae974a485f413a2113503eed53cd6c53
10.1136/jclinpath-2013-201461