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    PLK1 and YY1 interaction in follicular lymphoma is associated with unfavourable outcome.

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    Authors
    Sandison, H
    Usher, S
    Karimiani, E
    Ashton, Garry
    Menasce, Lia P
    Radford, John A
    Linton, Kim M
    Byers, R
    Affiliation
    The Medical School, The University of Manchester, , Manchester, Greater Manchester, UK.
    Issue Date
    2013-09
    
    Metadata
    Show full item record
    Abstract
    Ying Yang 1 (YY1) is a transcription factor involved in both proliferation and apoptosis. It is prognostic in follicular lymphoma (FL), increased protein levels being associated with favourable outcome. PLK1 is a critical regulator of mitosis, playing a role in spindle formation and in regulation of the G2/M cell cycle checkpoint. PLK1 phosphorylates YY1 at the G2/M checkpoint with activation of YY1 and resultant progression from G2 into mitosis.
    Citation
    PLK1 and YY1 interaction in follicular lymphoma is associated with unfavourable outcome. 2013, 66 (9):764-7 J Clin Pathol
    Journal
    Journal of Clinical Pathology
    URI
    http://hdl.handle.net/10541/302255
    DOI
    10.1136/jclinpath-2013-201461
    PubMed ID
    23757039
    Type
    Article
    Language
    en
    ISSN
    1472-4146
    ae974a485f413a2113503eed53cd6c53
    10.1136/jclinpath-2013-201461
    Scopus Count
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