Protein kinase cδ deficiency causes mendelian systemic lupus erythematosus with B cell-defective apoptosis and hyperproliferation.
Authors
Belot, AKasher, P
Trotter, Eleanor W
Foray, A-P
Debaud, A-L
Rice, G
Szynkiewicz, M
Zabot, M-T
Rouvet, I
Bhaskar, S
Daly, S
Dickerson, J
Mayer, J
O'Sullivan, J
Juillard, L
Urquhart, J
Fawdar, Shameem
Marusiak, A
Stephenson, N
Waszkowycz, B
Beresford, M W
Biesecker, L
Black, G
René, C
Eliaou, J-F
Fabien, N
Ranchin, B
Cochat, P
Gaffney, P
Rozenberg, F
Lebon, P
Malcus, C
Crow, Y
Brognard, John
Bonnefoy, N
Affiliation
Centre de Référence des Maladies Rénales Rares, Hospices Civils de Lyon, INSERM U1111, UMS3444/US8, Université Claude Bernard Lyon 1, and Université de Lyon, Lyon, France.Issue Date
2013-08
Metadata
Show full item recordAbstract
Systemic lupus erythematosus (SLE) is a prototype autoimmune disease that is assumed to occur via a complex interplay of environmental and genetic factors. Rare causes of monogenic SLE have been described, providing unique insights into fundamental mechanisms of immune tolerance. The aim of this study was to identify the cause of an autosomal-recessive form of SLE.Citation
Protein kinase cδ deficiency causes mendelian systemic lupus erythematosus with B cell-defective apoptosis and hyperproliferation. 2013, 65 (8):2161-71 Arthritis RheumJournal
Arthritis and RheumatismDOI
10.1002/art.38008PubMed ID
23666743Type
ArticleLanguage
enISSN
1529-0131ae974a485f413a2113503eed53cd6c53
10.1002/art.38008
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