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dc.contributor.authorHoneychurch, Jamieen_GB
dc.contributor.authorDive, Carolineen_GB
dc.contributor.authorIllidge, Timothy Men_GB
dc.date.accessioned2013-08-30T13:47:13Z
dc.date.available2013-08-30T13:47:13Z
dc.date.issued2013-06-01
dc.identifier.citationSynchronous apoptosis in established tumors leads to the induction of adaptive immunity. 2013, 2 (6):e24501 Oncoimmunologyen_GB
dc.identifier.issn2162-4011
dc.identifier.pmid23894711
dc.identifier.doi10.4161/onci.24501
dc.identifier.urihttp://hdl.handle.net/10541/300440
dc.description.abstractUnderstanding the immune response to the death of malignant cells is critical for the development of therapeutic strategies designed to stimulate the immune system against cancer. We have developed an inducible caspase-3-mediated death switch model to explore the effects of apoptosis on the host immune system, demonstrating that the synchronous apoptotic demise of established tumors can be immunogenic and elicit anticancer T-cell responses.
dc.languageENG
dc.language.isoenen
dc.rightsArchived with thanks to Oncoimmunologyen_GB
dc.titleSynchronous apoptosis in established tumors leads to the induction of adaptive immunity.en
dc.typeArticleen
dc.contributor.departmentTargeted Therapy Group; Institute of Cancer Science; Paterson Institute for Cancer Research; Manchester University; Manchester Cancer Research Centre; Manchester Academic Health Sciences Centres; Manchester UK.en_GB
dc.identifier.journalOncoimmunologyen_GB
html.description.abstractUnderstanding the immune response to the death of malignant cells is critical for the development of therapeutic strategies designed to stimulate the immune system against cancer. We have developed an inducible caspase-3-mediated death switch model to explore the effects of apoptosis on the host immune system, demonstrating that the synchronous apoptotic demise of established tumors can be immunogenic and elicit anticancer T-cell responses.


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