Synchronous apoptosis in established tumors leads to the induction of adaptive immunity.
Affiliation
Targeted Therapy Group; Institute of Cancer Science; Paterson Institute for Cancer Research; Manchester University; Manchester Cancer Research Centre; Manchester Academic Health Sciences Centres; Manchester UK.Issue Date
2013-06-01
Metadata
Show full item recordAbstract
Understanding the immune response to the death of malignant cells is critical for the development of therapeutic strategies designed to stimulate the immune system against cancer. We have developed an inducible caspase-3-mediated death switch model to explore the effects of apoptosis on the host immune system, demonstrating that the synchronous apoptotic demise of established tumors can be immunogenic and elicit anticancer T-cell responses.Citation
Synchronous apoptosis in established tumors leads to the induction of adaptive immunity. 2013, 2 (6):e24501 OncoimmunologyJournal
OncoimmunologyDOI
10.4161/onci.24501PubMed ID
23894711Type
ArticleLanguage
enISSN
2162-4011ae974a485f413a2113503eed53cd6c53
10.4161/onci.24501