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    Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone in patients with newly diagnosed diffuse large B-cell non-Hodgkin lymphoma: a phase 3 comparison of dose intensification with 14-day versus 21-day cycles.

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    Authors
    Cunningham, D
    Hawkes, E
    Jack, A
    Qian, W
    Smith, P
    Mouncey, P
    Pocock, C
    Ardeshna, K
    Radford, John A
    McMillan, A
    Davies, J
    Turner, D
    Kruger, A
    Johnson, P
    Gambell, J
    Linch, D
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    Affiliation
    Royal Marsden NHS Foundation Trust, London and Surrey, UK. david.cunningham@rmh.nhs.uk
    Issue Date
    2013-05-25
    
    Metadata
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    Abstract
    Dose intensification with a combination of cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP) every 2 weeks improves outcomes in patients older than 60 years with diffuse large B-cell lymphoma compared with CHOP every 3 weeks. We investigated whether this survival benefit from dose intensification persists in the presence of rituximab (R-CHOP) in all age groups.
    Citation
    Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone in patients with newly diagnosed diffuse large B-cell non-Hodgkin lymphoma: a phase 3 comparison of dose intensification with 14-day versus 21-day cycles. 2013, 381 (9880):1817-26 Lancet
    Journal
    Lancet
    URI
    http://hdl.handle.net/10541/297415
    DOI
    10.1016/S0140-6736(13)60313-X
    PubMed ID
    23615461
    Type
    Article
    Language
    en
    ISSN
    1474-547X
    ae974a485f413a2113503eed53cd6c53
    10.1016/S0140-6736(13)60313-X
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