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    The variety of leukemic stem cells in myeloid malignancy.

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    Authors
    Wiseman, Daniel H
    Greystoke, Brigit F
    Somervaille, Tim C P
    Affiliation
    Cancer Research UK Leukaemia Biology Laboratory, Paterson Institute for Cancer Research, The University of Manchester, Manchester, UK.
    Issue Date
    2013
    
    Metadata
    Show full item record
    Abstract
    Human acute myeloid leukemias (AMLs) are sustained by leukemic stem cells (LSCs) that generate through aberrant differentiation the blast cells that make up the bulk of the malignant clone. LSCs were first identified as rare cells with an immunophenotype shared with normal hematopoietic stem cells (HSCs). However, refinements of xenotransplantation assays, alternative methods of quantitation and syngeneic murine models have all led to an appreciation that LSCs display marked variability in frequency, immunophenotype and differentiation potential, both between and even within leukemias. Insights from next-generation sequencing efforts have dramatically extended understanding of the mutational landscape and clonal organization of AML and have added an additional layer of complexity to the biology of LSCs: a requirement to consider the effect of the various recurrently occurring genetic lesions in AML on the initiation and maintenance of leukemic subclones. Despite these advances, cure rates in AML remain substantially unchanged in recent years. A renewed focus on the biological properties of chemotherapy-resistant LSCs, a cellular entity of prime clinical importance, will be required to develop additional therapeutic strategies to enhance patient outcomes.
    Citation
    The variety of leukemic stem cells in myeloid malignancy.2013 Oncogene
    Journal
    Oncogene
    URI
    http://hdl.handle.net/10541/297409
    DOI
    10.1038/onc.2013.269
    PubMed ID
    23831573
    Type
    Article
    Language
    en
    ae974a485f413a2113503eed53cd6c53
    10.1038/onc.2013.269
    Scopus Count
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    All Paterson Institute for Cancer Research

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