Mitomycin or cisplatin chemoradiation with or without maintenance chemotherapy for treatment of squamous-cell carcinoma of the anus (ACT II): a randomised, phase 3, open-label, 2 × 2 factorial trial.
Authors
James, RGlynne-Jones, R
Meadows, H
Cunningham, D
Myint, A
Saunders, Mark P
Maughan, T
McDonald, A
Essapen, S
Leslie, M
Falk, S
Wilson, C
Gollins, S
Begum, R
Ledermann, J
Kadalayil, L
Sebag-Montefiore, D
Affiliation
The Kent Cancer Centre, Maidstone, UK.Issue Date
2013-05
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Show full item recordAbstract
Chemoradiation became the standard of care for anal cancer after the ACT I trial. However, only two-thirds of patients achieved local control, with 5-year survival of 50%; therefore, better treatments are needed. We investigated whether replacing mitomycin with cisplatin in chemoradiation improves response, and whether maintenance chemotherapy after chemoradiation improves survival.Citation
Mitomycin or cisplatin chemoradiation with or without maintenance chemotherapy for treatment of squamous-cell carcinoma of the anus (ACT II): a randomised, phase 3, open-label, 2 × 2 factorial trial. 2013, 14 (6):516-24 Lancet OncolJournal
The Lancet OncologyDOI
10.1016/S1470-2045(13)70086-XPubMed ID
23578724Type
ArticleLanguage
enISSN
1474-5488ae974a485f413a2113503eed53cd6c53
10.1016/S1470-2045(13)70086-X
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