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    Mitomycin or cisplatin chemoradiation with or without maintenance chemotherapy for treatment of squamous-cell carcinoma of the anus (ACT II): a randomised, phase 3, open-label, 2 × 2 factorial trial.

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    Authors
    James, R
    Glynne-Jones, R
    Meadows, H
    Cunningham, D
    Myint, A
    Saunders, Mark P
    Maughan, T
    McDonald, A
    Essapen, S
    Leslie, M
    Falk, S
    Wilson, C
    Gollins, S
    Begum, R
    Ledermann, J
    Kadalayil, L
    Sebag-Montefiore, D
    Show allShow less
    Affiliation
    The Kent Cancer Centre, Maidstone, UK.
    Issue Date
    2013-05
    
    Metadata
    Show full item record
    Abstract
    Chemoradiation became the standard of care for anal cancer after the ACT I trial. However, only two-thirds of patients achieved local control, with 5-year survival of 50%; therefore, better treatments are needed. We investigated whether replacing mitomycin with cisplatin in chemoradiation improves response, and whether maintenance chemotherapy after chemoradiation improves survival.
    Citation
    Mitomycin or cisplatin chemoradiation with or without maintenance chemotherapy for treatment of squamous-cell carcinoma of the anus (ACT II): a randomised, phase 3, open-label, 2 × 2 factorial trial. 2013, 14 (6):516-24 Lancet Oncol
    Journal
    The Lancet Oncology
    URI
    http://hdl.handle.net/10541/295471
    DOI
    10.1016/S1470-2045(13)70086-X
    PubMed ID
    23578724
    Type
    Article
    Language
    en
    ISSN
    1474-5488
    ae974a485f413a2113503eed53cd6c53
    10.1016/S1470-2045(13)70086-X
    Scopus Count
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