Mind the IQGAP.
| dc.contributor.author | Sanchez-Laorden, Berta | |
| dc.contributor.author | Viros, Amaya | |
| dc.contributor.author | Marais, Richard | |
| dc.date.accessioned | 2013-07-08T15:01:10Z | |
| dc.date.available | 2013-07-08T15:01:10Z | |
| dc.date.issued | 2013-06-10 | |
| dc.identifier.citation | Mind the IQGAP. 2013, 23 (6):715-7 Cancer Cell | en_GB |
| dc.identifier.issn | 1878-3686 | |
| dc.identifier.pmid | 23763998 | |
| dc.identifier.doi | 10.1016/j.ccr.2013.05.017 | |
| dc.identifier.uri | http://hdl.handle.net/10541/295470 | |
| dc.description.abstract | The scaffold protein IQGAP1 regulates cell signaling through the RAF/MEK/ERK pathway. Recent data show that cancer cells in which the RAF/MEK/ERK pathway is activated are particularly sensitive to the disruption of IQGAP1 function. IQGAP drugs may be particularly effective in tumors that develop resistance to existing pathway drugs. | |
| dc.language.iso | en | en |
| dc.rights | Archived with thanks to Cancer cell | en_GB |
| dc.title | Mind the IQGAP. | en |
| dc.type | Article | en |
| dc.contributor.department | Molecular Oncology Group, The Paterson Institute for Cancer Research, Manchester M20 4, UK. | en_GB |
| dc.identifier.journal | Cancer Cell | en_GB |
| html.description.abstract | The scaffold protein IQGAP1 regulates cell signaling through the RAF/MEK/ERK pathway. Recent data show that cancer cells in which the RAF/MEK/ERK pathway is activated are particularly sensitive to the disruption of IQGAP1 function. IQGAP drugs may be particularly effective in tumors that develop resistance to existing pathway drugs. |