AffiliationMolecular Oncology Group, The Paterson Institute for Cancer Research, Manchester M20 4, UK.
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AbstractThe scaffold protein IQGAP1 regulates cell signaling through the RAF/MEK/ERK pathway. Recent data show that cancer cells in which the RAF/MEK/ERK pathway is activated are particularly sensitive to the disruption of IQGAP1 function. IQGAP drugs may be particularly effective in tumors that develop resistance to existing pathway drugs.
CitationMind the IQGAP. 2013, 23 (6):715-7 Cancer Cell