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    Mind the IQGAP.

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    Authors
    Sanchez-Laorden, Berta
    Viros, Amaya
    Marais, Richard
    Affiliation
    Molecular Oncology Group, The Paterson Institute for Cancer Research, Manchester M20 4, UK.
    Issue Date
    2013-06-10
    
    Metadata
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    Abstract
    The scaffold protein IQGAP1 regulates cell signaling through the RAF/MEK/ERK pathway. Recent data show that cancer cells in which the RAF/MEK/ERK pathway is activated are particularly sensitive to the disruption of IQGAP1 function. IQGAP drugs may be particularly effective in tumors that develop resistance to existing pathway drugs.
    Citation
    Mind the IQGAP. 2013, 23 (6):715-7 Cancer Cell
    Journal
    Cancer Cell
    URI
    http://hdl.handle.net/10541/295470
    DOI
    10.1016/j.ccr.2013.05.017
    PubMed ID
    23763998
    Type
    Article
    Language
    en
    ISSN
    1878-3686
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ccr.2013.05.017
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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