• Login
    View Item 
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    •   Home
    • The Manchester Institute Cancer Research UK
    • All Paterson Institute for Cancer Research
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChristieCommunitiesTitleAuthorsIssue DateSubmit DateSubjectsThis CollectionTitleAuthorsIssue DateSubmit DateSubjects

    My Account

    LoginRegister

    Local Links

    The Christie WebsiteChristie Library and Knowledge Service

    Statistics

    Display statistics

    The recognition and removal of cellular poly(ADP-ribose) signals.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Barkauskaite, Eva
    Jankevicius, G
    Ladurner, A
    Ahel, Ivan
    Timinszky, G
    Affiliation
    Cancer Research UK, Paterson Institute for Cancer Research, University of Manchester, UK.
    Issue Date
    2013-05-26
    
    Metadata
    Show full item record
    Abstract
    Poly(ADP-ribosyl)ation is involved in the regulation of a variety of cellular pathways, including, but not limited to, transcription, chromatin, DNA damage and other stress signalling. Similar to other tightly regulated post-translational modifications, poly(ADP-ribosyl)ation employs 'writers', 'readers' and 'erasers' to confer regulatory functions. The generation of poly(ADP-ribose) is catalyzed by poly(ADP-ribose) polymerase enzymes, which use NAD(+) as a cofactor to sequentially transfer ADP-ribose units generating long polymers, which, in turn, can affect protein function or serve as a recruitment platform for additional factors. Historically, research has focused on poly(ADP-ribose) generation pathways, with knowledge about PAR recognition and degradation lagging behind. Over recent years, several discoveries have significantly furthered our understanding of poly(ADP-ribose) recognition and, even more so, of poly(ADP-ribose) degradation. In this review, we summarize current knowledge about the protein modules recognizing poly(ADP-ribose) and discuss the newest developments on the complete reversibility of poly(ADP-ribosyl)ation.
    Citation
    The recognition and removal of cellular poly(ADP-ribose) signals. 2013: FEBS J
    Journal
    The FEBS Journal
    URI
    http://hdl.handle.net/10541/295469
    DOI
    10.1111/febs.12358
    PubMed ID
    23711178
    Type
    Article
    Language
    en
    ISSN
    1742-4658
    ae974a485f413a2113503eed53cd6c53
    10.1111/febs.12358
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

    entitlement

    Related articles

    • Poly(ADP-ribose): PARadigms and PARadoxes.
    • Authors: Bürkle A, Virág L
    • Issue date: 2013 Dec
    • Functional Role of ADP-Ribosyl-Acceptor Hydrolase 3 in poly(ADP-Ribose) Polymerase-1 Response to Oxidative Stress.
    • Authors: Mashimo M, Moss J
    • Issue date: 2016
    • Importance of poly(ADP-ribose) glycohydrolase in the control of poly(ADP-ribose) metabolism.
    • Authors: Davidovic L, Vodenicharov M, Affar EB, Poirier GG
    • Issue date: 2001 Aug 1
    • The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase.
    • Authors: Slade D, Dunstan MS, Barkauskaite E, Weston R, Lafite P, Dixon N, Ahel M, Leys D, Ahel I
    • Issue date: 2011 Sep 4
    • Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions.
    • Authors: D'Amours D, Desnoyers S, D'Silva I, Poirier GG
    • Issue date: 1999 Sep 1
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.