[18F]DPA-714: direct comparison with [11C]PK11195 in a model of cerebral ischemia in rats.
Authors
Boutin, HPrenant, C
Maroy, R
Galea, J
Greenhalgh, A
Smigova, A
Cawthorne, C
Julyan, Peter J
Wilkinson, S
Banister, S
Brown, G
Herholz, K
Kassiou, M
Rothwell, N
Affiliation
Faculty of Medical and Human Sciences, University of Manchester, Manchester, United Kingdom.Issue Date
2013
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Neuroinflammation is involved in several brain disorders and can be monitored through expression of the translocator protein 18 kDa (TSPO) on activated microglia. In recent years, several new PET radioligands for TSPO have been evaluated in disease models. [(18)F]DPA-714 is a TSPO radiotracer with great promise; however results vary between different experimental models of neuroinflammation. To further examine the potential of [(18)F]DPA-714, it was compared directly to [(11)C]PK11195 in experimental cerebral ischaemia in rats.Citation
[18F]DPA-714: direct comparison with [11C]PK11195 in a model of cerebral ischemia in rats. 2013, 8 (2):e56441 PLoS ONEJournal
PloS OneDOI
10.1371/journal.pone.0056441PubMed ID
23418569Type
ArticleLanguage
enISSN
1932-6203ae974a485f413a2113503eed53cd6c53
10.1371/journal.pone.0056441
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