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    Tetracycline regulated systems in functional oncogenomics.

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    Authors
    Welman, Arkadiusz
    Barraclough, Jane
    Dive, Caroline
    Affiliation
    Cancer Research U.K., Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, United Kingdom.
    Issue Date
    2007
    
    Metadata
    Show full item record
    Abstract
    The increasing number of proteomic and DNA-microarray studies is continually providing a steady acquisition of data on the molecular abnormalities associated with human tumors. Rapid translation of this accumulating biological information into better diagnostics and more effective cancer therapeutics in the clinic depends on the use of robust function-testing strategies. Such strategies should allow identification of molecular lesions that are essential for the maintenance of the transformed phenotype and enable validation of potential drug-targets. The tetracycline regulated gene expression/ suppression systems (Tet-systems) developed and optimized by bioengineers over recent years seem to be very well suited for the function-testing purposes in cancer research. We review the history and latest improvements in Tet-technology in the context of functional oncogenomics.
    Citation
    Tetracycline regulated systems in functional oncogenomics. 2007, 2:17-33 Transl Oncogenomics
    Journal
    Translational Oncogenomics
    URI
    http://hdl.handle.net/10541/293992
    PubMed ID
    23645981
    Type
    Article
    Language
    en
    ISSN
    1177-2727
    Collections
    All Paterson Institute for Cancer Research

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