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    Identification of a functional prostanoid-like receptor in the protozoan parasite, trypanosoma cruzi.

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    Authors
    Mukherjee, S
    Sadekar, N
    Ashton, A
    Huang, H
    Spray, D
    Lisanti, Michael P
    Machado, F
    Weiss, L
    Tanowitz, H
    Affiliation
    Department of Pathology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, USA. sankar.mukhopadhyay@einstein.yu.edu
    Issue Date
    2013-04
    
    Metadata
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    Abstract
    Trypanosoma cruzi infection in humans and experimental animals causes Chagas disease which is often accompanied by myocarditis, cardiomyopathy, and vasculopathy. T. cruzi-derived thromboxane A2 (TXA2) modulates vasculopathy and other pathophysiological features of Chagasic cardiomyopathy. Here, we provide evidence that epimastigotes, trypomastigotes, and amastigotes of T. cruzi (Brazil and Tulahuen strains) express a biologically active prostanoid receptor (PR) that is responsive to TXA2 mimetics, e.g. IBOP. This putative receptor, TcPR, is mainly localized in the flagellar membrane of the parasites and shows a similar glycosylation pattern to that of bona fide thromboxane prostanoid (TP) receptors obtained from human platelets. Furthermore, TXA2-PR signal transduction activates T. cruzi-specific MAPK pathways. While mammalian TP is a G-protein coupled receptor (GPCR); T. cruzi genome sequencing has not demonstrated any confirmed GPCRs in these parasites. Based on this genome sequencing it is likely that TcPR is unique in these protists with no counterpart in mammals. TXA2 is a potent vasoconstrictor which contributes to the pathogenesis of Chagasic cardiovascular disease. It may, however, also control parasite differentiation and proliferation in the infected host allowing the infection to progress to a chronic state.
    Citation
    Identification of a functional prostanoid-like receptor in the protozoan parasite, trypanosoma cruzi. 2013, 112 (4):1417-25 Parasitol Res
    Journal
    Parasitology Research
    URI
    http://hdl.handle.net/10541/292376
    DOI
    10.1007/s00436-012-3271-5
    PubMed ID
    23403991
    Type
    Article
    Language
    en
    ISSN
    1432-1955
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00436-012-3271-5
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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