Dpb2 integrates the leading-strand DNA polymerase into the eukaryotic replisome.
Affiliation
Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.Issue Date
2013-04-08
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The eukaryotic replisome is a critical determinant of genome integrity with a complex structure that remains poorly characterized. A central unresolved issue is how the Cdc45-MCM-GINS helicase is linked to DNA polymerase epsilon, which synthesizes the leading strand at replication forks and is an important focus of regulation.Citation
Dpb2 integrates the leading-strand DNA polymerase into the eukaryotic replisome. 2013, 23 (7):543-52 Curr BiolJournal
Current BiologyDOI
10.1016/j.cub.2013.02.011PubMed ID
23499531Type
ArticleLanguage
enISSN
1879-0445ae974a485f413a2113503eed53cd6c53
10.1016/j.cub.2013.02.011
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