Dpb2 integrates the leading-strand DNA polymerase into the eukaryotic replisome.
AffiliationPaterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.
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AbstractThe eukaryotic replisome is a critical determinant of genome integrity with a complex structure that remains poorly characterized. A central unresolved issue is how the Cdc45-MCM-GINS helicase is linked to DNA polymerase epsilon, which synthesizes the leading strand at replication forks and is an important focus of regulation.
CitationDpb2 integrates the leading-strand DNA polymerase into the eukaryotic replisome. 2013, 23 (7):543-52 Curr Biol
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