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    Dpb2 integrates the leading-strand DNA polymerase into the eukaryotic replisome.

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    Authors
    Sengupta, Sugopa
    Van Deursen, Frederick
    de Piccoli, Giacomo
    Labib, Karim
    Affiliation
    Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.
    Issue Date
    2013-04-08
    
    Metadata
    Show full item record
    Abstract
    The eukaryotic replisome is a critical determinant of genome integrity with a complex structure that remains poorly characterized. A central unresolved issue is how the Cdc45-MCM-GINS helicase is linked to DNA polymerase epsilon, which synthesizes the leading strand at replication forks and is an important focus of regulation.
    Citation
    Dpb2 integrates the leading-strand DNA polymerase into the eukaryotic replisome. 2013, 23 (7):543-52 Curr Biol
    Journal
    Current Biology
    URI
    http://hdl.handle.net/10541/292375
    DOI
    10.1016/j.cub.2013.02.011
    PubMed ID
    23499531
    Type
    Article
    Language
    en
    ISSN
    1879-0445
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.cub.2013.02.011
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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