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    Carcinoma-associated fibroblasts: non-neoplastic tumour-promoting mesenchymal cells.

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    Authors
    Polanska, Urszula M
    Orimo, Akira
    Affiliation
    CR-UK Stromal-Tumour Interaction Group, Paterson Institute for Cancer Research, The University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.
    Issue Date
    2013-03-04
    
    Metadata
    Show full item record
    Abstract
    Cancerous stroma coevolves alongside tumour progression, thereby promoting the malignant conversion of epithelial carcinoma cells. To date, an abundance of data have supported crucial roles of the tumour microenvironment (TME) in providing cancer cells with proliferative, migratory, survival and invasive propensities favouring the processes of tumourigenesis. The cancerous reactive stroma is frequently populated by a large number of myofibroblasts (MFs), which are activated, non-transformed fibroblasts expressing α-smooth muscle actin (α-SMA). MFs together with non-MF cells present in the tumour-associated stroma are collectively referred to as carcinoma-associated fibroblasts (CAFs), one of the major stromal cell types recognised in various human carcinomas. Recruitment of fibroblasts and/or their progenitors to a tumour mass and their subsequent transdifferentiation into MFs, as well as ongoing maintenance of their activated state, are believed to be essential processes facilitating tumour progression. However, the complex networks of signalling pathways mediating the phenotypic conversion into CAFs, as well as those underlying their tumour-promoting interactions with other tumour-constituting cells, have yet to be fully explored. Histopathological confirmation of the presence of large numbers of CAF MFs within TME and their altered gene expression profiles are known to be associated with disease progression and to serve as independent negative prognostic factors for a wide range of tumour types. In this review, we examine the current evidence shedding light on the emerging roles of tumour-promoting CAFs, cells that are pivotal for epithelial cancer development and progression, and discuss the therapeutic potential of targeting these cells. J. Cell. Physiol. © 2013 Wiley Periodicals, Inc.
    Citation
    Carcinoma-associated fibroblasts: non-neoplastic tumour-promoting mesenchymal cells. 2013: J Cell Physiol
    Journal
    Journal of Cellular Physiology
    URI
    http://hdl.handle.net/10541/279112
    DOI
    10.1002/jcp.24347
    PubMed ID
    23460038
    Type
    Article
    Language
    en
    ISSN
    1097-4652
    ae974a485f413a2113503eed53cd6c53
    10.1002/jcp.24347
    Scopus Count
    Collections
    All Paterson Institute for Cancer Research

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