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    Radical treatment of non-small cell lung cancer during the last 5 years.

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    Authors
    McCloskey, Paula
    Balduyck, B
    Van Schil, P
    Faivre-Finn, Corinne
    O'Brien, M
    Affiliation
    Radiotherapy Related Research, The Christie NHS Foundation Trust, Manchester, United Kingdom.
    Issue Date
    2013-01-23
    
    Metadata
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    Abstract
    The management of non-small cell lung cancer (NSCLC) has continued to improve over the last 5years due to advances in surgery, radiological staging, combined modality therapies and advances in radiation technology. We have an updated staging classification (7th Edition American Joint Committee on Cancer staging) and now in 2011, a new histology classification introducing the concepts of adenocarcinoma in situ and minimally invasive adenocarcinoma. This classification has profound surgical implications as the role of limited resection is reconsidered for early stage lesions. Surgery is curative in early stage disease. The role of surgery in locally advanced NSCLC remains controversial. The principal aim is a complete resection as this will determine long-term prognosis. Intraoperative staging of lung cancer is extremely important to determine the extent of resection according to the tumour and nodal status. Systematic nodal dissection is generally advocated to obtain accurate intraoperative staging and to help decide on adjuvant therapy. Radiotherapy currently plays a major role in the management of lung cancer as most patients are not surgical candidates due to disease stage, fitness and co-morbidities. In the last 5years we have seen continuing optimisation of chemo-radiotherapy combinations and technological advances including the development of image guided radiotherapy (IGRT), stereotactic ablative body radiotherapy (SABR) and intensity modulated radiotherapy (IMRT). Quality of life evaluation is becoming increasingly important and should be considered when deciding on a specific treatment, especially in a multimodality setting.
    Citation
    Radical treatment of non-small cell lung cancer during the last 5 years. 2013: Eur J Cancer
    Journal
    European Journal of Cancer
    URI
    http://hdl.handle.net/10541/273004
    DOI
    10.1016/j.ejca.2012.12.023
    PubMed ID
    23352436
    Type
    Article
    Language
    en
    ISSN
    1879-0852
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ejca.2012.12.023
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