Removal of Centrosomal PP1 by NIMA Kinase Unlocks the MPF Feedback Loop to Promote Mitotic Commitment in S. pombe.
Authors
Grallert, AgnesChan, Kuan Yoow
Alonso-Nunez, Maria-Luisa
Madrid, Marisa
Biswas, Ashapurna
Alvarez-Tabares, Isabel
Connolly, Yvonne
Tanaka, Kayoko
Robertson, Alasdair M
Ortiz, J
Smith, Duncan L
Hagan, Iain M
Affiliation
CRUK Cell Division Group, Paterson Institute for Cancer Research, University of Manchester, Wilmslow Road, Manchester M20 4BX, UK.Issue Date
2013-02-04
Metadata
Show full item recordAbstract
Activation of the Cdk1/cyclin B complex, also known as mitosis-promoting factor (MPF), drives commitment to mitosis. Interphase MPF is inhibited through phosphorylation of Cdk1 by Wee1-related kinases. Because Cdc25 phosphatases remove this phosphate, Cdc25 activity is an essential part of the switch that drives cells into mitosis. The generation of a critical "trigger" of active MPF promotes a positive feedback loop that employs Polo kinase to boost Cdc25 activity and inhibit Wee1, thereby ensuring that mitotic commitment is a bistable switch. Mutations in the spindle pole body (SPB) component Cut12 suppress otherwise lethal deficiencies in Cdc25.Citation
Removal of Centrosomal PP1 by NIMA Kinase Unlocks the MPF Feedback Loop to Promote Mitotic Commitment in S. pombe. 2013, 23 (3):213-22 Curr BiolJournal
Current BiologyDOI
10.1016/j.cub.2012.12.039PubMed ID
23333317Type
ArticleLanguage
enISSN
1879-0445ae974a485f413a2113503eed53cd6c53
10.1016/j.cub.2012.12.039
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