The MYSTerious MOZ, a Histone Acetyltransferase with a Key Role in Haematopoiesis.
Affiliation
Cancer Research UK Stem Cell Biology Group, Paterson Institute for Cancer Research, The University of Manchester, Wilmslow road, M20 4BX, UK.Issue Date
2013-01-24
Metadata
Show full item recordAbstract
Cells of the immune system are generated from multipotent haematopoietic stem cells (HSCs) through an elaborated process of differentiation. Self-renewal of the HSC and a tightly controlled differentiation are therefore vital to replenish the blood and immune system throughout the lifespan of an organism. HSCs proliferation, as well as the successive stages of differentiation into more committed progenitors, are regulated at the transcriptional level through epigenetic modifications. These modifications include DNA methylation, histone modifications (such as acetylation, methylation, phosphorylation, SUMOylation and ubiquitylation) and chromatin remodeling. The enzymes responsible for these chromatin modifications are therefore critical for normal blood and immune system homeostasis. The finding that these chromatin modifiers are common targets of mutations or translocations in leukaemia further highlights their functional requirements. © 2013 The Paterson Institute for Cancer Research Immunology © 2013 Blackwell Publishing Ltd.Citation
The MYSTerious MOZ, a Histone Acetyltransferase with a Key Role in Haematopoiesis. 2013: ImmunologyJournal
ImmunologyDOI
10.1111/imm.12072PubMed ID
23347099Type
ArticleLanguage
enISSN
1365-2567ae974a485f413a2113503eed53cd6c53
10.1111/imm.12072