The MYSTerious MOZ, a Histone Acetyltransferase with a Key Role in Haematopoiesis.
AffiliationCancer Research UK Stem Cell Biology Group, Paterson Institute for Cancer Research, The University of Manchester, Wilmslow road, M20 4BX, UK.
MetadataShow full item record
AbstractCells of the immune system are generated from multipotent haematopoietic stem cells (HSCs) through an elaborated process of differentiation. Self-renewal of the HSC and a tightly controlled differentiation are therefore vital to replenish the blood and immune system throughout the lifespan of an organism. HSCs proliferation, as well as the successive stages of differentiation into more committed progenitors, are regulated at the transcriptional level through epigenetic modifications. These modifications include DNA methylation, histone modifications (such as acetylation, methylation, phosphorylation, SUMOylation and ubiquitylation) and chromatin remodeling. The enzymes responsible for these chromatin modifications are therefore critical for normal blood and immune system homeostasis. The finding that these chromatin modifiers are common targets of mutations or translocations in leukaemia further highlights their functional requirements. © 2013 The Paterson Institute for Cancer Research Immunology © 2013 Blackwell Publishing Ltd.
CitationThe MYSTerious MOZ, a Histone Acetyltransferase with a Key Role in Haematopoiesis. 2013: Immunology
- The histone acetyl transferase activity of monocytic leukemia zinc finger is critical for the proliferation of hematopoietic precursors.
- Authors: Perez-Campo FM, Borrow J, Kouskoff V, Lacaud G
- Issue date: 2009 May 14
- MOZ is essential for maintenance of hematopoietic stem cells.
- Authors: Katsumoto T, Aikawa Y, Iwama A, Ueda S, Ichikawa H, Ochiya T, Kitabayashi I
- Issue date: 2006 May 15
- Roles of the histone acetyltransferase monocytic leukemia zinc finger protein in normal and malignant hematopoiesis.
- Authors: Katsumoto T, Yoshida N, Kitabayashi I
- Issue date: 2008 Aug
- MOZ and MORF, two large MYSTic HATs in normal and cancer stem cells.
- Authors: Yang XJ, Ullah M
- Issue date: 2007 Aug 13
- MOZ fusion proteins in acute myeloid leukaemia.
- Authors: Troke PJ, Kindle KB, Collins HM, Heery DM
- Issue date: 2006