AffiliationManchester Breast Centre and Breakthrough Breast Cancer Research Unit, Paterson Institute for Cancer Research; Institute of Cancer Sciences, Manchester Academic Health Science Centre, University of Manchester, UK.
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AbstractIn the model of metabolic-coupling, the oxidative capacity of the tumor mitochondria and the concomitant bypassing of autophagy both act in concert to support cancer growth. Therefore, it is not unlikely that the mitochondrial citrate carrier, SLC25A1 or CIC is also involved in the positive-feedback and crosstalk provided by the stroma. It will be important to determine whether CIC impinges upon other tumor-promoting metabolic branches, particularly the catabolism of glutamine.
CitationGenetic induction of the warburg effect inhibits tumor growth. 2012, 3 (11):1266-7 Oncotarget
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