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    The Implementation of the Gynaecological Groupe Européen de Curiethérapie - European Society for Therapeutic Radiology and Oncology Radiobiology Considerations in the Conversion of Low Dose Rate to Pulsed Dose Rate Treatment Schedules for Gynaecological Brachytherapy.

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    Authors
    Baker, S
    Pooler, Alistair
    Hendry, Jolyon H
    Davidson, S
    Affiliation
    The Christie Hospital, Manchester, UK.
    Issue Date
    2012-12-04
    
    Metadata
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    Abstract
    AIMS: This paper details the considerations and calculations made by this centre for the implementation of the biologically equivalent dose in 2 Gy fractions (EQD(2)) radiobiology calculations recommended by the Gynaecological Groupe Européen de Curiethérapie - European Society for Therapeutic Radiology and Oncology, in converting our cervix, body of uterus and vaginal vault low dose rate (LDR) treatment prescription schedules for caesium-137 to equivalent pulsed dose rate (PDR) protocols using iridium-192. MATERIALS AND METHODS: The assumptions made in order to calculate the EQD(2) for both the LDR and the corresponding PDR schedules are detailed. The source geometries and prescription points are discussed for all standard treatment schedules. The prescription point for vaginal vault treatments has been altered to a 5 mm depth rather than the applicator surface, and the prescribed dose for all applicator sizes has been normalised at this depth. RESULTS: The calculated PDR schedules are presented, with corresponding target and organ at risk values given for LDR and PDR versions of standard treatment schedules. A standard 32.5 Gy point A cervix prescription used in Manchester with LDR has been converted to 2 × 19 Gy for PDR. CONCLUSIONS: PDR schedules have been calculated to correspond with our established LDR treatments in terms of EQD(2) dose to the target. There is a theoretical improvement in the therapeutic ratio due to a reduction in the calculated EQD(2) to organs at risk.
    Citation
    The Implementation of the Gynaecological Groupe Européen de Curiethérapie - European Society for Therapeutic Radiology and Oncology Radiobiology Considerations in the Conversion of Low Dose Rate to Pulsed Dose Rate Treatment Schedules for Gynaecological Brachytherapy. 2012: Clin Oncol
    Journal
    Clinical Oncology
    URI
    http://hdl.handle.net/10541/265201
    DOI
    10.1016/j.clon.2012.11.005
    PubMed ID
    23218875
    Type
    Article
    Language
    en
    ISSN
    1433-2981
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.clon.2012.11.005
    Scopus Count
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