Affiliation
Department of Medical Oncology, The Christie NHS Foundation Trust, Wilmslow Road, Manchester, M20 4BX, UK.Issue Date
2012-11
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Show full item recordAbstract
Letrozole is a type 2 aromatase inhibitor, which reduces availability of estrogen in postmenopausal women, thereby decreasing its ability to stimulate breast cancer cells. Phase III trials in both the advanced and early breast cancer setting have shown an improvement in disease-free survival compared with other compounds, including tamoxifen. Letrozole is well-tolerated, with the main adverse effects reported as hot flushes, arthritis, arthralgia and myalgia, and a trend towards increased risk of fracture.Citation
Letrozole: advancing hormone therapy in breast cancer. 2012, 8 (6):611-8 Womens HealthJournal
Womens HealthDOI
10.2217/whe.12.49PubMed ID
23181527Type
ArticleLanguage
enISSN
1745-5065ae974a485f413a2113503eed53cd6c53
10.2217/whe.12.49
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