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    Biomarker Utility of Circulating Tumor Cells in Metastatic Cutaneous Melanoma.

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    Authors
    Khoja, Leila
    Lorigan, Paul C
    Zhou, Cong
    Lancashire, Matthew
    Booth, Jessica
    Cummings, Jeffrey
    Califano, Raffaele
    Clack, G
    Hughes, Andrew
    Dive, Caroline
    Affiliation
    Clinical and Experimental Pharmacology Group, Paterson Institute for Cancer Research, Manchester, UK.
    Issue Date
    2012-12-06
    
    Metadata
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    Abstract
    The incidence of melanoma is increasing worldwide. Advances in targeted agents and immunotherapy have improved outcomes in metastatic disease, but biomarkers are required to optimize treatment. We determined the prevalence of circulating tumor cells (CTCs) and explored their utility as prognostic and pharmacodynamic biomarkers. A total of 101 patients with metastatic cutaneous melanoma were recruited prospectively. CTC number was determined using the CellSearch platform and melanoma kits in samples taken at baseline and serially during treatment. CTC numbers ranged between 0 and 36 per 7.5 ml blood; 26% of patients had 2 CTCs. Baseline CTC number was prognostic for median overall survival (OS) in univariate analysis (2.6 vs. 7.2 months (P<0.011) for patients with 2 CTCs vs. <2 CTCs, respectively). In multivariate analysis, CTC number was an independent prognostic biomarker of OS (hazard ratio (HR) 2.403, 95% confidence interval (CI) 1.303-4.430, P=0.005). Patients receiving treatment in whom CTC number remained 2 CTCs during treatment had shorter median OS than those who maintained <2 CTCs (7 vs. 10 months, HR 0.34, 95% CI 0.14-0.81, log-rank test P=0.015). In conclusion, CTC number in metastatic cutaneous melanoma patients is prognostic for OS with a cutoff of 2 CTCs per 7.5 ml blood. CTC number measured before and throughout treatment provided additional prognostic information. Larger studies are warranted to confirm CTC biomarker utility in melanoma patients.Journal of Investigative Dermatology advance online publication, 6 December 2012; doi:10.1038/jid.2012.468.
    Citation
    Biomarker Utility of Circulating Tumor Cells in Metastatic Cutaneous Melanoma. 2012: J Invest Dermatol
    Journal
    The Journal of Investigative Dermatology
    URI
    http://hdl.handle.net/10541/265176
    DOI
    10.1038/jid.2012.468
    PubMed ID
    23223143
    Type
    Article
    Language
    en
    ISSN
    1523-1747
    ae974a485f413a2113503eed53cd6c53
    10.1038/jid.2012.468
    Scopus Count
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