Three cytotoxic drugs combined with pelvic radiation and as maintenance chemotherapy for patients with squamous cell carcinoma of the anus (SCCA): long-term follow-up of a phase II pilot study using 5-fluorouracil, mitomycin C and cisplatin.
| dc.contributor.author | Sebag-Montefiore, D | |
| dc.contributor.author | Meadows, H | |
| dc.contributor.author | Cunningham, D | |
| dc.contributor.author | Plowman, P | |
| dc.contributor.author | Hurman, D | |
| dc.contributor.author | Davidson, N | |
| dc.contributor.author | Grieve, R | |
| dc.contributor.author | Levine, Edward | |
| dc.contributor.author | Glynne-Jones, R | |
| dc.date.accessioned | 2012-12-28T15:45:43Z | |
| dc.date.available | 2012-12-28T15:45:43Z | |
| dc.date.issued | 2012-08 | |
| dc.identifier.citation | Three cytotoxic drugs combined with pelvic radiation and as maintenance chemotherapy for patients with squamous cell carcinoma of the anus (SCCA): long-term follow-up of a phase II pilot study using 5-fluorouracil, mitomycin C and cisplatin. 2012, 104 (2):155-60 Radiother Oncol | en_GB |
| dc.identifier.issn | 1879-0887 | |
| dc.identifier.pmid | 22857859 | |
| dc.identifier.doi | 10.1016/j.radonc.2012.06.006 | |
| dc.identifier.uri | http://hdl.handle.net/10541/263692 | |
| dc.description.abstract | Phase III trials in the 1990s for squamous cell carcinoma of the anus (SCCA) demonstrated 5-fluorouracil (5FU) and mitomycinC (MMC) chemoradiation (CRT) improved outcome compared to radiation (RT) alone, but local recurrence remained significant. This prospective pilot study intensified treatment by integrating 3 cytotoxic drugs into CRT and maintenance chemotherapy. | |
| dc.language.iso | en | en |
| dc.rights | Archived with thanks to Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology | en_GB |
| dc.title | Three cytotoxic drugs combined with pelvic radiation and as maintenance chemotherapy for patients with squamous cell carcinoma of the anus (SCCA): long-term follow-up of a phase II pilot study using 5-fluorouracil, mitomycin C and cisplatin. | en |
| dc.type | Article | en |
| dc.contributor.department | University of Leeds, St. James's Institute of Oncology, Leeds, UK. | en_GB |
| dc.identifier.journal | Radiotherapy and Oncology | en_GB |
| html.description.abstract | Phase III trials in the 1990s for squamous cell carcinoma of the anus (SCCA) demonstrated 5-fluorouracil (5FU) and mitomycinC (MMC) chemoradiation (CRT) improved outcome compared to radiation (RT) alone, but local recurrence remained significant. This prospective pilot study intensified treatment by integrating 3 cytotoxic drugs into CRT and maintenance chemotherapy. |