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dc.contributor.authorHughes, Carynen_GB
dc.contributor.authorIqbal-Wahid, Junaiden_GB
dc.contributor.authorBrown, Michael Den_GB
dc.contributor.authorShanks, Jonathan Hen_GB
dc.contributor.authorEustace, Amandaen_GB
dc.contributor.authorDenley, Hen_GB
dc.contributor.authorHoskin, Pen_GB
dc.contributor.authorWest, Catharine M Len_GB
dc.contributor.authorClarke, Noel Wen_GB
dc.contributor.authorGardner, Pen_GB
dc.date.accessioned2012-12-28T16:11:59Z
dc.date.available2012-12-28T16:11:59Z
dc.date.issued2012-11-02
dc.identifier.citationFTIR microspectroscopy of selected rare diverse sub-variants of carcinoma of the urinary bladder. 2012: J Biophotonicsen_GB
dc.identifier.issn1864-0648
dc.identifier.pmid23125109
dc.identifier.doi10.1002/jbio.201200126
dc.identifier.urihttp://hdl.handle.net/10541/263686
dc.description.abstractUrothelial carcinomas of the bladder are a heterogeneous group of tumours, although some histological sub-variants are rare and sparsely reported in the literature. Diagnosis of sub-variants from conventional urothelial carcinoma can be challenging, as they may mimic the morphology of other malignancies or benign tumours and therefore their distinction is important. For the first time, the spectral pathology of some of these sub-variants has been documented by infrared microspectroscopy and an attempt made to profile their biochemistry. It is important not only to identify and separate the cancer-associated epithelial tissue spectra from common tissue features such as stroma or blood, but also to detect the signatures of tumour sub-variants. As shown, their spectroscopic signals can change dramatically as a consequence of differentiation. Example cases are discussed and compared with histological evaluations. (© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim).
dc.languageENG
dc.language.isoenen
dc.rightsArchived with thanks to Journal of biophotonicsen_GB
dc.titleFTIR microspectroscopy of selected rare diverse sub-variants of carcinoma of the urinary bladder.en
dc.typeArticleen
dc.contributor.departmentManchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK;en_GB
dc.identifier.journalJournal of Biophotonicsen_GB
html.description.abstractUrothelial carcinomas of the bladder are a heterogeneous group of tumours, although some histological sub-variants are rare and sparsely reported in the literature. Diagnosis of sub-variants from conventional urothelial carcinoma can be challenging, as they may mimic the morphology of other malignancies or benign tumours and therefore their distinction is important. For the first time, the spectral pathology of some of these sub-variants has been documented by infrared microspectroscopy and an attempt made to profile their biochemistry. It is important not only to identify and separate the cancer-associated epithelial tissue spectra from common tissue features such as stroma or blood, but also to detect the signatures of tumour sub-variants. As shown, their spectroscopic signals can change dramatically as a consequence of differentiation. Example cases are discussed and compared with histological evaluations. (© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim).


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